Results 131 to 140 of about 76,007 (204)

From Hierarchical Capitalism to Developmental Governance: The Emergence of Concerted Skills Formation in Middle‐Income Countries

open access: yesRegulation &Governance, EarlyView.
ABSTRACT Skills formation is a pressing issue for middle‐income countries given the pace of technological change. In Latin America, scholars point to the hierarchical type of capitalism and its segmentalist skills formation system as the main roadblocks to exiting the middle‐income trap.
Aldo Madariaga, Mariana Rangel‐Padilla
wiley   +1 more source

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray   +16 more
wiley   +1 more source

Delayed CPK peak after primary PCI in STEMI: marker of reperfusion quality and short-term outcomes. [PDF]

open access: yesBMC Cardiovasc Disord
Umehara E   +10 more
europepmc   +1 more source

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich   +5 more
wiley   +1 more source

TRIP8bnano peptide prevents cAMP binding to HCN2 channels alleviating pain‐like behaviors in rats with neuropathic pain

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez   +7 more
wiley   +1 more source

A method of compensating for the excitability of spinal motoneurones when estimating the magnitude of potentials evoked in skeletal muscles

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend There is positive covariation in the amplitudes of motor evoked potentials (MEPs) in skeletal muscles generated by transcranial magnetic stimulation (TMS) of the motor cortex and in fluctuations in the excitability of spinal motoneurones – as indexed by electromyography (EMG), in the period (e.g. 100 ms) immediately preceding the
Richard G. Carson
wiley   +1 more source

Integrated Metabolomic and Transcriptomic Analysis Revealed the Capsanthin Biosynthesis and Sequestration in Processing Type Red Pepper (Capsicum annuum var. conoides)

open access: yeseFood, Volume 7, Issue 4, August 2026.
This study establishes that fruit color divergence in Yanjiao pepper cultivars arises from hierarchical regulation of carotenoid metabolism, driven by yellow‐blue chromaticity variation and cultivar‐specific metabolic strategies. These findings provide a mechanistic framework for breeding peppers with enhanced color stability and nutraceutical value ...
Qi Chen   +5 more
wiley   +1 more source

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