Results 171 to 180 of about 7,735,427 (345)

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Multiple risk factor interventions for primary prevention of coronary heart disease [PDF]

, 1999
Shah Ebrahim, George Davey Smith
openalex   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Trends in Glycemic and Cardiovascular Risks Control in Cantonese Adults in Primary Healthcare Settings: 2018 to 2022

Diabetes, Metabolic Syndrome and Obesity
Xueji Wu,1,2 Liumei Fan,3 Xiongfei Chen,2,4 Meiting Huang,5 Xinghua Zhang3 1Corporate Operations Office, Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, People’s Republic of China; 2Institute of Public Health, Guangzhou Medical
Wu X, Fan L, Chen X, Huang M, Zhang X
doaj  

A preliminary economic evaluation of a potential program for the primary prevention of Alzheimer's disease. [PDF]

J Prev Alzheimers Dis
Mattke S, Chen J, Reiman EM.
europepmc   +1 more source

Evaluation of the effectiveness of the stay safe primary prevention programme for child sexual abuse

, 1999
Deirdre MacIntyre, Alan Carr
openalex   +2 more sources

Can primary prevention or selective screening for melanoma be more precisely targeted through general practice? A prospective study to validate a self administered risk score [PDF]

, 1998
Arthur Jackson, Clare Wilkinson, M. Ranger, Roisin Pill, Phyllis August   +4 more
openalex   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

Lancet Neurology, 2014
S. Norton, F. Matthews, D. Barnes, K. Yaffe, C. Brayne   +4 more
semanticscholar   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source