Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Diabetes, Metabolic Syndrome and ObesityXueji Wu,1,2 Liumei Fan,3 Xiongfei Chen,2,4 Meiting Huang,5 Xinghua Zhang3 1Corporate Operations Office, Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, People’s Republic of China; 2Institute of Public Health, Guangzhou Medical
Wu X, Fan L, Chen X, Huang M, Zhang X
doaj
Connecticut's substance use primary prevention resource assessment and interactive map initiative. [PDF]
Public Health Pract (Oxf)Cunningham SD +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Cardiosphere-derived cells in the primary prevention of sepsis-induced acute lung injury in pigs. [PDF]
PLoS OneDawkins JF +8 more
europepmc +1 more source
DEVELOPING A COMMUNITY-BASED COMPREHENSIVE FALLS PREVENTION PROGRAM IN COLLABORATION WITH PRIMARY CARE [PDF]
, 2019 Dawna Pidgeon
openalex +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Potential for primary prevention of Alzheimer's disease: an analysis of population-based data
Lancet Neurology, 2014 S. Norton +4 more
semanticscholar +1 more source
Lack of current implantable cardioverter defibrillator guidelines application for primary prevention of sudden cardiac death in Latin American patients with heart failure: a cross-sectional study [PDF]
, 2012 Jorge González‐Zuelgaray +10 more
openalex +1 more source