Results 211 to 220 of about 7,735,427 (345)

Primary Prevention of Cardiovascular Disease in Asia: Challenges: A Narrative Review. [PDF]

JACC Adv
Dalakoti M, Lin NHY, Yap J, Cader A, Dipanker P, Lee D, Raja Shariff RE, Cuenza L, Honda S, Malis V, Jiang H, Hirachan A, Chimura M, Yeo TJ, Yeo KK, Tan JWC, Tromp J, Loh PH, Chew NWS, Wong S, Sia CH, Tan BYQ, Johar S, Lip GYH, Yang E, Virani SS, Hageman S, Liu H, Di Angelantonio E, Dorairaj P, Koh AS, Chin C, Al Mahmeed W, Chan MY, Foo R.   +34 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Scoping review of dementia primary prevention policies in England: do they balance reach and agency? [PDF]

BMJ Public Health
Walsh S, Birch JM, Merrick R, Wallace L, Kuhn I, Clare L, Mytton OT, Lafortune L, Wills WJ, Brayne CE.   +9 more
europepmc   +1 more source

Accounting for cluster randomization: a review of primary prevention trials, 1990 through 1993.

, 1995
Judy M. Simpson, Neil Klar, A Donnor
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Primary Prevention Aspirin, Lipoprotein(a), and Cardiorenal Outcomes in Chronic Kidney Disease: Chronic Renal Insufficiency Cohort. [PDF]

JACC Adv
Razavi AC, Chen J, Yang W, Sha D, Dzaye O, Bhatia HS, Tsimikas S, Lash JP, Kansal M, Rincon-Choles H, Vaccarino V, Jacobson TA, Budoff MJ, Blumenthal RS, Whelton SP, Sperling LS, Blaha MJ, He J, CRIC Study Investigators.   +18 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Implications of five different risk models in primary prevention guidelines. [PDF]

Eur Heart J Qual Care Clin Outcomes
Sud M, Sivaswamy A, Austin PC, Abdel-Qadir H, Anderson TJ, Naimark DMJ, Lee DS, Roifman I, Thanassoulis G, Tu K, Wijeysundera HC, Ko DT.   +11 more
europepmc   +1 more source

FETAL ALCOHOL SYNDROME (FAS) PRIMARY PREVENTION THROUGH FAS DIAGNOSIS: II. A COMPREHENSIVE PROFILE OF 80 BIRTH MOTHERS OF CHILDREN WITH FAS [PDF]

, 2000
Susan J. Astley
openalex   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source