Results 211 to 220 of about 7,915,710 (337)

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

What is the Role of Primary Prevention of Obesity in an Age of Effective Pharmaceuticals? [PDF]

Curr Obes Rep
Gómez-Martín M, Canfell OJ, Chai LK, Jansson AK, Littlewood R, Sullivan C, Power D, Clarke ED, Ells L, De Vlieger N, Burrows TL, Collins CE.   +11 more
europepmc   +1 more source

Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting

Circulation, 2017
P. Natarajan, R. Young, N. Stitziel, S. Padmanabhan, U. Baber, R. Mehran, S. Sartori, V. Fuster, Dermot F. Reilly, A. Butterworth, D. Rader, I. Ford, N. Sattar, S. Kathiresan   +13 more
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Upper extremity pain after stroke: a systematic review and meta-analysis on primary prevention. [PDF]

Eur J Phys Rehabil Med
Denizli MA, Everard G, Dessart P, Hatem SM.   +3 more
europepmc   +1 more source

4144A telemonitoring program for primary and secondary prevention of cardiovascular disease [PDF]

, 2017
Laura Lupi, Fulvio Glisenti, Assunta Castiello, Emanuele Visco, Ilaria Papa, Elisabetta Dinatolo, Gianmarco Arabia, Savina Nodari   +7 more
openalex   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Cardiovascular Morbidity and Mortality Attributable to Potentially Inappropriate Medication Use Among Primary Prevention Populations - China, 2015-2023. [PDF]

China CDC Wkly
Zhao Z, Zhang M, Wang L, Zhou M.
europepmc   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

The Association of Lipoprotein(A) and Coronary Artery Calcium in Primary Prevention Patients-Data from the STAR-Lp(A) Study. [PDF]

J Clin Med
Burzyńska M, Jankowski P, Babicki M, Banach M, Chudzik M.   +4 more
europepmc   +1 more source