Results 231 to 240 of about 7,915,710 (337)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Primary Prevention of Cardiovascular Disease in Asia: Challenges: A Narrative Review. [PDF]

JACC Adv
Dalakoti M, Lin NHY, Yap J, Cader A, Dipanker P, Lee D, Raja Shariff RE, Cuenza L, Honda S, Malis V, Jiang H, Hirachan A, Chimura M, Yeo TJ, Yeo KK, Tan JWC, Tromp J, Loh PH, Chew NWS, Wong S, Sia CH, Tan BYQ, Johar S, Lip GYH, Yang E, Virani SS, Hageman S, Liu H, Di Angelantonio E, Dorairaj P, Koh AS, Chin C, Al Mahmeed W, Chan MY, Foo R.   +34 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Metformin for primary prevention of colorectal neoplasms in adenoma-free populations: a systematic review and dose-response meta-analysis. [PDF]

Front Pharmacol
Shen M, Lu S, Xu Z, Zhou F, Sheng LT, Yu Q.   +5 more
europepmc   +1 more source

Aspirin for Primary Prevention of Cardiovascular Events.

Journal of the American College of Cardiology, 2019
Hesham K. Abdelaziz, Marwan Saad, N. Pothineni, M. Megaly, R. Potluri, Mohammed Saleh, D. L. C. Kon, D. Roberts, Deepak L. Bhatt, H. Aronow, J. Abbott, J. Mehta   +11 more
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Implications of five different risk models in primary prevention guidelines. [PDF]

Eur Heart J Qual Care Clin Outcomes
Sud M, Sivaswamy A, Austin PC, Abdel-Qadir H, Anderson TJ, Naimark DMJ, Lee DS, Roifman I, Thanassoulis G, Tu K, Wijeysundera HC, Ko DT.   +11 more
europepmc   +1 more source