Results 241 to 250 of about 7,915,710 (337)

Metformin for primary colorectal cancer prevention in patients with diabetes: A case‐control study in a US population

, 2014
Amikar Sehdev, Ya‐Chen Tina Shih, B. G. Vekhter, Marc B. Bissonnette, Olufunmilayo I. Olopade, Blasé N. Polite   +5 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Cholesterol Levels and Cardiovascular Outcomes Following Statin Initiation for Primary Prevention: A Cohort Study. [PDF]

JACC Adv
Thompson W, Jeong I, Basque S, Abdel-Qadir H, Austin PC, Ko DT, Famiyeh I, Chu A, Fang J, Odutayo A, Jackevicius CA, Godoy LC, Lee DS, Anderson TJ, Udell JA.   +14 more
europepmc   +1 more source

Primary prevention of ocular injury in agricultural workers with safety eyewear

, 2017
Samrat Chatterjee, Deepshikha Agrawal
openalex   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Scoping review of dementia primary prevention policies in England: do they balance reach and agency? [PDF]

BMJ Public Health
Walsh S, Birch JM, Merrick R, Wallace L, Kuhn I, Clare L, Mytton OT, Lafortune L, Wills WJ, Brayne CE.   +9 more
europepmc   +1 more source

Sixth Grade Students Who Use Alcohol: Do We Need Primary Prevention Programs for “Tweens”?

, 2008
Keryn E. Pasch, Cheryl L. Perry, Melissa H. Stigler, Kelli A. Komro   +3 more
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Sex Differences in Cardiovascular Health Status and Long-Term Outcomes in a Primary Prevention Cohort. [PDF]

JACC Adv
Sud M, Chaudhry A, Qui F, Haldenby O, Godoy LC, Austin PC, Roifman I, Manuel D, Eurich DT, Wijeysundera HC, Madan M, Huynh T, Ko DT.   +12 more
europepmc   +1 more source