Results 21 to 30 of about 7,735,427 (345)

Primary polymerization prevention [PDF]

Blood, 2019
In this issue of Blood, Howard et al report a phase 1/2 study of voxelotor (GBT440) in sickle cell anemia. This drug binds to the α-globin chain of hemoglobin and increases hemoglobin-oxygen affinity, thereby decreasing the polymerization tendency of deoxygenated sickle hemoglobin (HbS).
openaire   +3 more sources

Coronary Artery Calcium for Personalized Allocation of Aspirin in Primary Prevention of Cardiovascular Disease in 2019

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Recent American College of Cardiology/American Heart Association Primary Prevention Guidelines recommended considering low-dose aspirin therapy only among adults 40 to 70 years of age who
M. Cainzos‐Achirica, M. Miedema, J. McEvoy, Mahmoud Al Rifai, P. Greenland, Z. Dardari, M. Budoff, R. Blumenthal, J. Yeboah, D. Duprez, M. Mortensen, O. Dzaye, Jonathan C. Hong, K. Nasir, M. Blaha   +14 more
semanticscholar   +1 more source

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease.

Circulation, 2019
The American Heart Association requests that this document be cited as follows: Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, Michos ED, Miedema MD, Muñoz D, Smith SC Jr, Virani
Donna K. Arnett, R. Blumenthal, Michelle A. Albert, Andrew B. Buroker, Z. Goldberger, Ellen J. Hahn, C. D. Himmelfarb, Amit Khera, Donald M. Lloyd-Jones, J. William McEvoy, Erin D. Michos, M. Miedema, D. Muñoz, Sidney C. Smith, Salim S. Virani, Kim A. Williams, Joseph Yeboah, B. Ziaeian   +17 more
semanticscholar   +1 more source

Association of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events: A Systematic Review and Meta-analysis

Journal of the American Medical Association (JAMA), 2019
Importance The role for aspirin in cardiovascular primary prevention remains controversial, with potential benefits limited by an increased bleeding risk.
Sean Zheng, A. Roddick
semanticscholar   +1 more source

Examining income-related inequality in health literacy and health-information seeking among urban population in China

BMC Public Health, 2019
Background Health literacy and health-information seeking behaviour (HISB) play vital roles in health outcome improvements. This study examines the extent of income-related inequality in health literacy and health-information seeking as well as the ...
Chengxiang Tang, Xueji Wu, Xiongfei Chen, Bingying Pan, Xiaocong Yang   +4 more
doaj   +1 more source

Adherence to antihypertensive medication in Russia: a scoping review of studies on levels, determinants and intervention strategies published between 2000 and 2017

Archives of Public Health, 2019
Background Arterial hypertension (HT) is common in the Russian adult population, with half of affected individuals inadequately controlled. Low adherence to medication seems likely to be a factor.
Elena Viktorovna Bochkareva, Ekaterina Kronidovna Butina, Irina Vitalievna Kim, Anna Vasilievna Kontsevaya, Oxana Mikhailovna Drapkina, David Leon, Martin McKee   +6 more
doaj   +1 more source

Attachment-based compassion therapy and adapted mindfulness-based stress reduction for the treatment of depressive, anxious and adjustment disorders in mental health settings: a randomised controlled clinical trial protocol

BMJ Open, 2019
Introduction Depressive, anxiety and adjustment disorders are highly prevalent among mental health outpatients. The lack of funding for mental health problems produces inefficient results and a high burden of disease.
Jesus Montero-Marin, Carlos Collado-Navarro, Mayte Navarro-Gil, Alba Lopez-Montoyo, Marcelo Demarzo, Paola Herrera-Mercadal, Alberto Barcelo-Soler, Javier Garcia-Campayo   +7 more
doaj   +1 more source

Combined use of smartphone and smartband technology in the improvement of lifestyles in the adult population over 65 years: study protocol for a randomized clinical trial (EVIDENT-Age study)

BMC Geriatrics, 2019
Background The increasing use of smartphones by older adults also increases their potential for improving different aspects of health in this population.
José I. Recio-Rodríguez, Cristina Lugones-Sanchez, Cristina Agudo-Conde, Jesús González-Sánchez, Olaya Tamayo-Morales, Susana Gonzalez-Sanchez, Carmen Fernandez-Alonso, Jose A. Maderuelo-Fernandez, Sara Mora-Simon, Manuel A. Gómez-Marcos, Emiliano Rodriguez-Sanchez, Luis Garcia-Ortiz   +11 more
doaj   +1 more source

Discrimination between Obstructive Coronary Artery Disease and Cardiac Syndrome X in Women with Typical Angina and Positive Exercise Test; Utility of Cardiovascular Risk Calculators

Medicina, 2019
Introduction: Nearly 40% of women with typical angina and a positive exercise tolerance test (ETT) have normal or near normal coronary angiography (CAG) labeled as cardiac syndrome X (CSX).
Mohammad Saadat, Farzad Masoudkabir, Mohsen Afarideh, Saeed Ghodsi, Ali Vasheghani-Farahani   +4 more
doaj   +1 more source

Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus

New England Journal of Medicine, 2018
BACKGROUND Diabetes mellitus is associated with an increased risk of cardiovascular events. Aspirin use reduces the risk of occlusive vascular events but increases the risk of bleeding; the balance of benefits and hazards for the prevention of first ...
L. Bowman, M. Mafham, K. Wallendszus, W. Stevens, G. Buck, J. Barton, K. Murphy, Theingi Aung, R. Haynes, J. Cox, A. Murawska, A. Young, M. Lay, Fang Chen, E. Sammons, Emma Waters, A. Adler, J. Bodansky, A. Farmer, R. Mcpherson, A. Neil, D. Simpson, R. Peto, C. Baigent, R. Collins, S. Parish, J. Armitage   +26 more
semanticscholar   +1 more source