Results 141 to 150 of about 5,609,357 (351)

Forest Resilience Threshold Experiment (FoRTE) - Scaling and analysis of aboveground wood net primary production (ANPPw)

open access: green, 2020
Maxim Grigri   +4 more
openalex   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Primary Production

open access: yesPrimary Production
The phytoplankton and macrophytes are the main primary producers in the ecosystem of Tonle Sap Lake (TSL). The average biomasses of the phytoplankton and macrophytes in TSL were estimated at 5.48 ton/km2 and 1489 ton/km2, with the ratios of production to biomass being 185/year and 1.67/year, respectively.
openaire  

Effect of electrolyzed oxidizing water on reducing Campylobacter spp. in broiler chikken at primary production [PDF]

open access: hybrid, 2014
Eva-Maria Bügener   +3 more
openalex   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Linking Upwelling Dynamics and Subsurface Nutrients to Projected Productivity Changes in the California Current System

open access: yesGeophysical Research Letters
Given the importance of coastal upwelling systems to ocean productivity, fisheries, and biogeochemical cycles, their response to climate change is of great interest.
Michael G. Jacox   +8 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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