Results 181 to 190 of about 5,546,226 (282)

Landscape determinants of pelagic and benthic primary production in northern lakes. [PDF]

Glob Chang Biol, 2022
Puts IC, Ask J, Siewert MB, Sponseller RA, Hessen DO, Bergström AK.   +5 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Diurnal pattern of respiration in corals and algae and its implications for gross primary production quantification. [PDF]

PLoS One
Sawall Y, Bakker R, Padillo-Anthemides NE, Adamson N.   +3 more
europepmc   +1 more source

Nutrient uptake plasticity in phytoplankton sustains future ocean net primary production. [PDF]

Sci Adv, 2022
Kwon EY, Sreeush MG, Timmermann A, Karl DM, Church MJ, Lee SS, Yamaguchi R.   +6 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Global decline in net primary production underestimated by climate models. [PDF]

Commun Earth Environ
Ryan-Keogh TJ, Tagliabue A, Thomalla SJ.
europepmc   +1 more source

Environmental controls on the light use efficiency of terrestrial gross primary production. [PDF]

Glob Chang Biol, 2023
Bloomfield KJ, Stocker BD, Keenan TF, Prentice IC.   +3 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Dataset of reference values for the quantification of net primary production use (or biotic resource use) of feed ingredients in life cycle assessment. [PDF]

Data Brief
Le Féon S, Aubin J, Wilfart A.
europepmc   +1 more source

Spatio-temporal assessment of the impacts of the trends in physical and biogeochemical parameters on the primary production of the Gulf of Guinea. [PDF]

Heliyon, 2023
Dahunsi AM, Oyikeke TS, Abdulfatai MA, Afolabi LA.   +3 more
europepmc   +1 more source