Results 211 to 220 of about 5,546,226 (282)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Seafloor primary production in a changing Arctic Ocean. [PDF]

Proc Natl Acad Sci U S A
Attard K, Singh RK, Gattuso JP, Filbee-Dexter K, Krause-Jensen D, Kühl M, Sejr MK, Archambault P, Babin M, Bélanger S, Berg P, Glud RN, Hancke K, Jänicke S, Qin J, Rysgaard S, Sørensen EB, Tachon F, Wenzhöfer F, Ardyna M.   +19 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Identifying a growth and survival bottleneck: oceanic zooplankton abundance and Faroe shelf primary production jointly influence the survival of Faroe Plateau cod larvae. [PDF]

J Plankton Res
Jacobsen S, Vang HBM, Eliasen SK, Húsgarð Larsen KM, Gaard E, Grønkjær P, Hátún H.   +6 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

A 30-m gross primary production dataset from 2016 to 2020 in China. [PDF]

Sci Data
Lin S, Huang X, Wang C, He T, Zhang X, Shen R, Peng Q, Chen X, Zheng Y, Dong J, Liang S, Yuan W.   +11 more
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Marine plankton community and net primary production responding to island-trapped waves in a stratified oligotrophic ecosystem. [PDF]

Heliyon
Ljubešić Z, Mihanović H, Matek A, Mucko M, Achterberg EP, Omand M, Pestorić B, Lučić D, Čižmek H, Čolić B, Balestra C, Casotti R, Janeković I, Orlić M.   +13 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Possible Missing Sources of Atmospheric Glyoxal Part II: Oxidation of Toluene Derived from the Primary Production of Marine Microorganisms. [PDF]

Metabolites
Williams RT, Caspers-Brown A, Michaud J, Stevens N, Meehan M, Sultana CM, Lee C, Malfatti F, Zhou Y, Azam F, Prather KA, Dorrestein P, Burkart MD, Pomeroy RS.   +13 more
europepmc   +1 more source