Results 211 to 220 of about 609,852 (306)

Efficacy of non -thermal pressure plasma versus other modalities for disinfection of primary root canals. [PDF]

BMC Oral Health
El Shishiny SA, Morad YO, Hindi RI, El-Motasem AM, El Sheshiny AA, Alramady DM, Samy AM.   +6 more
europepmc   +1 more source

Long-term tooth survival and success following primary root canal treatment: a 5- to 37-year retrospective observation. [PDF]

Clin Oral Investig, 2023
López-Valverde I, Vignoletti F, Vignoletti G, Martin C, Sanz M.   +4 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The effect of pomegranate peel extract and apple cider vinegar as an irrigants in disinfecting the necrotic primary root canal. [PDF]

Sci Rep
Mando A, Laflouf M, Achour H, Alsalameh SA, Alsayed Tolibah Y.   +4 more
europepmc   +1 more source

The Hierarchy of Protoxylem Groupings in Primary Root and Their Plasticity to Nitrogen Addition in Three Tree Species. [PDF]

Front Plant Sci, 2022
Li Z, Wang S, Wang W, Gu J, Wang Y.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

HDC1 Promotes Primary Root Elongation by Regulating Auxin and K⁺ Homeostasis in Response to Low-K⁺ Stress. [PDF]

Biology (Basel)
Kuang X, Chen H, Xiang J, Zeng J, Liu Q, Su Y, Huang C, Wang R, Lin W, Huang Z.   +9 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Forgotten Actors: Glycoside Hydrolases During Elongation Growth of Maize Primary Root. [PDF]

Front Plant Sci, 2021
Nazipova A, Gorshkov O, Eneyskaya E, Petrova N, Kulminskaya A, Gorshkova T, Kozlova L.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source