Results 141 to 150 of about 3,665,788 (354)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

PRIMARY SCHOOL STUDENTS’ LEISURE TIME POSSIBILITIES [PDF]

, 2021
Slobodno vrijeme, kao fenomen, tijekom povijesti se različito shvaćalo. Iako nema jednoznačnu definiciju, ali u ovome radu promatrat će se kao vrijeme kada „mladi nisu formalno angažirani u školskim, kućanskim ili radnim aktivnostima“ (Irby i Tolman 2002 prema Livazović 2019).
openaire  

Studying at home: worth it? [PDF]

, 2018
Homework time and its effect on students’ academic achievement is a relevant subject with worldwide repercussion. Nevertheless, although transcendental, this issue has been studied for primary education mostly by correlational studies and their results ...
Jerrim, John, López-Agudo, Luis Alejandro, Marcenaro-Gutiérrez, Óscar David   +2 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Optimizing Student Management to Improve Educational Service Quality: A Qualitative Case Study in Integrated Islamic Elementary Schools

Edukasia
This study examines how the quality of educational services can be improved through the optimization of student management implementation. The research was conducted at an Integrated Islamic Elementary School in Bandung.
Annisa Mayasari, Opan Arifudin, Silvi Herawati, Atik Rosanti, Rachmad Agung Prayogi   +4 more
doaj   +1 more source

The effect of social trust on achievement test performance of students in Japan [PDF]

Empirical results using Japanese data suggest that social trust improves student language and mathematics achievement test scores in primary and junior high school.
Yamamura, Eiji
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A Preliminary Analysis of SACMEQ III South Africa [PDF]

The many and varied links between student socio-economic status and educational outcomes have been well documented in the South African economics of education literature. The strong legacy of apartheid and the consequent correlation between education and
Nic Spaull
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

The Impact of Early Schooling on Subsequent Literacy and Numeracy Performance - Estimates from a Policy Induced 'Natural' Experiment [PDF]

This paper exploits a policy-induced natural experiment that occurred in South Australia in the mid-1980s to generate a 'causal' estimate of the effect of schooling on the literacy and numeracy performance of school students in their middle years of ...
Chris Ryan
core