Results 151 to 160 of about 1,206,897 (310)

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

open access: yesAdvanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian   +13 more
wiley   +1 more source

GloPath: An Entity‐Centric Foundation Model for Glomerular Lesion Assessment and Clinicopathological Insights

open access: yesAdvanced Science, EarlyView.
An entity‐centric foundation model, GloPath, is introduced for comprehensive glomerular lesion assessment from routine renal biopsy images. Trained on over one million glomeruli, the framework enables robust lesion recognition, grading, and cross modality diag nosis, while uncovering large‐scale clinicopathological associations.
Qiming He   +28 more
wiley   +1 more source

Diagnosing features of personal-professional primary school teacher [PDF]

open access: yes, 2013
У статті подано діагностичну методику, за допомогою якої кожен учитель початкової школи матиме змогу продіагностувати особливості особистісно-професійної діяльності, виокремити лише йому характерні ознаки та педагогічні якості.В статье представлены ...
Мартиненко, Світлана Миколаївна
core  

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

open access: yesAdvanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu   +7 more
wiley   +1 more source

Assessment in homeschooling: Emerging topics

open access: yesRicerche di Pedagogia e Didattica
The spread of homeschooling practices in many countries responds to the need of many families to find an alternative to traditional school offerings that respect the well-being, potential and learning times of the child. Assessment, a fundamental element
Emilia Restiglian, Serena Busato
doaj   +1 more source

Hey, this school library isn't what it used to be: The change process and the sociopolitical realities of implementing a curricularly integrated information literacy program [PDF]

open access: yes, 2006
This study sought to add to the knowledge and understanding of the organizational change process for successfully implementing an integrated information literacy program in one American high school.
Rojtas-Milliner, Mary Cay
core   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

open access: yesAdvanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Worker absence and shirking: evidence from matched teacher-school data [PDF]

open access: yes
We utilise a unique matched teacher-school data set of absenteeism records to quantify shirking behaviour in primary and secondary schools. Shirking behaviour is shown to vary systematically across schools, and hence schools are characterised as either ...
Colin Green, G Leeves, S Bradley
core   +1 more source

Science for primary school teachers

open access: yes, 2007
Biblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 planta; 28014 Madrid; Tel.
Gillespie, Helena, Gillespie, Rob
openaire   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

open access: yesAdvanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng   +8 more
wiley   +1 more source

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