Results 11 to 20 of about 62,620 (348)

Sarcoidosis mimicking primary sclerosing cholangitis requiring liver transplantation

Annals of Hepatology, 2008
Sarcoidosis is a systemic granulomatous disease of unknown etiology. The association of the cholestatic pattern usually seen in sarcoidosis, with biliary duct changes resembling primary sclerosing cholangitis (PSC) is rare.1 Liver transplantation permits
Claudio Tombazzi, Bradford Waters, Mohammad K. Ismail, Pamela B. Sylvestre, Antonio Martinez-Hernandez, Caroline A. Riely   +5 more
doaj   +2 more sources

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nature Microbiology, 2019
Nobuhiro Nakamoto, Wataru Suda, Po-sung Chu   +2 more
exaly   +2 more sources

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk [PDF]

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, M L Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, J. Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
openalex   +2 more sources

Primary sclerosing cholangitis – a comprehensive review

Journal of Hepatology, 2017
Tom H Karlsen, Trine Folseraas
exaly   +2 more sources

Risks of colorectal cancer and biliary cancer according to accompanied primary sclerosing cholangitis in Korean patients with ulcerative colitis: a nationwide population-based study [PDF]

Intestinal Research, 2023
Background/Aims We conducted a nationwide population-based study to investigate incidence rates of colorectal and biliary cancers according to accompanying primary sclerosing cholangitis in Korean ulcerative colitis patients.
Eun Hye Oh, Ye-Jee Kim, Minju Kim, Seung Ha Park, Tae Oh Kim, Sang Hyoung Park   +5 more
doaj   +1 more source

Primary sclerosing cholangitis

Best Practice & Research Clinical Gastroenterology, 2010
Primary sclerosing cholangitis (PSC) is a chronic bile duct disease leading to fibrotic biliary strictures and liver cirrhosis. The patient population is heterogeneous with regard to disease progression and the presence of co-morbidities, complicating the practical handling of patients as well as studies of pathogenetic mechanisms. The aetiology of PSC
Tom H, Karlsen, Erik, Schrumpf, Kirsten Muri, Boberg   +2 more
  +7 more sources

AASLD Practice Guidance on Primary Sclerosing Cholangitis and Cholangiocarcinoma.

Hepatology, 2022
Pathogenesis of PSC. The current model of the pathogenesis of PSC involves four major themes on a background of underlying genetic and environmental risk factors.
C. Bowlus, L. Arrivé, A. Bergquist, M. Deneau, L. Forman, S. Ilyas, K. Lunsford, Mercedes Martinez, Gonzalo Sapisochin, R. Shroff, J. Tabibian, D. Assis   +11 more
semanticscholar   +1 more source

Primary Biliary Cholangitis and Primary Sclerosing Cholangitis: Current Knowledge of Pathogenesis and Therapeutics

Biomedicines, 2022
Cholangiopathies encompass various biliary diseases affecting the biliary epithelium, resulting in cholestasis, inflammation, fibrosis, and ultimately liver cirrhosis.
Ji-won Park, Jung-Hee Kim, Sung-Eun Kim, J. Jung, M. Jang, S. Park, Myung‐Seok Lee, H. Kim, K. Suk, D. J. Kim   +9 more
semanticscholar   +1 more source

Primary sclerosing cholangitis with partial steroid responsiveness: a case report

Fujita Medical Journal, 2023
A 69-year-old woman suspected to have IgG4-related sclerosing cholangitis causing bile duct stenosis was transferred from another hospital after diarrhea, eosinophilia, and eosinophilic infiltration were detected and prednisolone was prescribed ...
Satoshi Yamamoto, Kazuo Inui, Yoshiaki Katano, Hironao Miyoshi, Kenji Notohara   +4 more
doaj   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source