Results 11 to 20 of about 39,460 (147)

The natural history of primary sclerosing cholangitis in 781 children. A multicenter, international collaboration [PDF]

, 2017
There are limited data on the natural history of primary sclerosing cholangitis (PSC) in children. We aimed to describe the disease characteristics and long-term outcomes of pediatric PSC.
Abdou, Reham, Alqoaer, Khaled, Amin, Mansi, Amir, Achiya Z, Auth, Marcus, Bazerbachi, Fateh, Broderick, Annemarie, Chan, Albert, Cotter, Jillian, Deneau, Mark R, Doan, Sylvia, El-Matary, Wael, El-Youssef, Mounif, Ferrari, Federica, Furuya, Katryn N, Gottrand, Frederic, Gottrand, Madeleine, Gupta, Nitika, Homan, Matjaz, Iorio, Raffaele, Jensen, M K, Kamath, Binita M, Kolho, Kaija-Leena, Konidari, Anastasia, Koot, Bart, Ledder, Oren, Mack, Cara, Martinez, Mercedes, Miloh, Tamir, Mo Kim, Kyung, Mohan, Parvathi, O'Cathain, Niamh, Papadopoulou, Alexandra, Ricciuto, Amanda, Sathya, Pushpa, Saubermann, Lawrence, Shteyer, Eyal, Smolka, Vratislav, Tanaka, Atushi, Valentino, Pamela L, Varier, Raghu, Venkat, Veena, Vitola, Bernadette, Vos, Miriam B, Woynarowski, Marek, Yap, Jason   +45 more
core   +6 more sources

Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning

Hepatology, 2020
Improved methods are needed to risk stratify and predict outcomes in patients with primary sclerosing cholangitis (PSC). Therefore, we sought to derive and validate a prediction model and compare its performance to existing surrogate markers.
J. Eaton, M. Vesterhus, Bryan M McCauley, E. Atkinson, E. Schlicht, B. Juran, A. Gossard, N. LaRusso, G. Gores, T. Karlsen, K. Lazaridis   +10 more
semanticscholar   +1 more source

Clinical Features and Risk Factors of Autoimmune Liver Involvement in Pediatric Inflammatory Bowel Disease [PDF]

, 2016
OBJECTIVES:Autoimmune liver disease is reported in up to 7.8% of children with inflammatory bowel disease. A distinct inflammatory bowel disease phenotype has been suggested in adults and in small pediatric cohorts.
Alexopoulou, Alvarez, Block, Boonstra, Deneau, Dotson, Faubion, Feldstein, Goyal, Gregorio, Halliday, Hirschfield, Hov, Jose, Jose, Levine, Levine, Liberal, Loftus, Loftus, Lundqvist, Maggiore, Malaty, Mieli-Vergani, Navaneethan, Noble-Jamieson, Olsson, Ordonez, Penna, Rönnblom, Sokol, Zholudev   +31 more
core   +1 more source

Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile

Hepatology, 2021
Primary sclerosing cholangitis (PSC) is associated with increased risk of cholangiocarcinoma (CCA). Early and accurate CCA detection represents an unmet clinical need as the majority of patients with PSC are diagnosed at an advanced stage of malignancy ...
H. M. Vedeld, Marit M. Grimsrud, K. Andresen, H. Pharo, Erik von Seth, T. Karlsen, H. Honne, V. Paulsen, M. Färkkilä, A. Bergquist, M. Jeanmougin, L. Aabakken, K. Boberg, T. Folseraas, G. E. Lind   +14 more
semanticscholar   +1 more source

Development of colon cancer after liver transplantation for primary sclerosing cholangitis associated with ulcerative colitis [PDF]

, 1990
Between February 26, 1981, and July 30, 1987, 36 patients underwent orthotopic liver transplantation for primary sclerosing cholangitis associated with ulcerative colitis.
Higashi, H, Kakizoe, S, Marsh, JW, Starzi, TE, Tzakis, A, Yanaga, K   +5 more
core   +1 more source

The incidence of portal vein thrombosis at liver transplantation [PDF]

, 1992
The incidence of portal vein thrombosis was examined in 885 patients who received orthotopic liver transplantations for various end‐stage liver diseases between 1989 and 1990. The thrombosis was classified into four grades.
Iwatsuki, S, Nonami, T, Starzl, TE, Yokoyama, I   +3 more
core   +1 more source

Monocytes as Potential Mediators of Pathogen‐Induced T‐Helper 17 Differentiation in Patients With Primary Sclerosing Cholangitis (PSC)

Hepatology, 2020
T cells from patients with primary sclerosing cholangitis (PSC) show a prominent interleukin (IL)‐17 response upon stimulation with bacteria or fungi, yet the reasons for this dominant T‐helper 17 (Th17) response in PSC are not clear.
Lilly K. Kunzmann, T. Schoknecht, T. Poch, L. Henze, S. Stein, M. Kriz, I. Grewe, M. Preti, J. Hartl, N. Pannicke, M. Peiseler, M. Sebode, R. Zenouzi, T. Horvatits, Marius Böttcher, B. Petersen, C. Weiler-Normann, Leonard U. Hess, Annika Elise Ahrenstorf, S. Lunemann, G. Martrus, L. Fischer, Jun Li, A. Carambia, J. Kluwe, S. Huber, A. Lohse, A. Franke, J. Herkel, C. Schramm, D. Schwinge   +30 more
semanticscholar   +1 more source

Primary sclerosing cholangitis.

Translational Gastroenterology and Hepatology, 2021
Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease characterized by inflammatory destruction of the intrahepatic and/or extrahepatic bile ducts, leading to bile stasis, fibrosis, and ultimately to cirrhosis, and often ...
A. Rabiee, M. Silveira
semanticscholar   +1 more source

A case report on severe nivolumab-induced adverse events similar to primary sclerosing cholangitis refractory to immunosuppressive therapy

Medicine, 2021
Introduction: Immune checkpoint inhibitors (ICIs), particularly anti-PD-1 antibody, have dramatically changed cancer treatment; however, fatal immune-related adverse events (irAEs) can develop.
Y. Hirasawa, K. Yoshimura, H. Matsui, Y. Kubota, H. Ishida, Jun Arai, M. Sakaki, N. Oguro, Midori Shida, Makoto Taniguchi, K. Hamada, H. Ariizumi, Tomoyuki Ishiguro, R. Ohkuma, T. Sambe, A. Horiike, C. Imamura, E. Shiozawa, S. Wada, J. Tsurutani, S. Iwamoto, N. Uchida, Y. Kiuchi, G. Tate, Shin'ichi Kobayashi, T. Tsunoda   +25 more
semanticscholar   +1 more source

Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholagnitis [PDF]

, 2018
The non-invasive differentiation of malignant and benign biliary disease is a clinical challenge. Carbohydrate antigen 19-9 (CA19-9), leucine-rich α2-glycoprotein (LRG1), interleukin 6 (IL6), pyruvate kinase M2 (PKM2), cytokeratin 19 fragment (CYFRA21.1)
Blyuss, O, Cuenco, J, Dawnay, A, Kazarian, A, Manns, MP, Menon, U, Pereira, SP, Timms, JF, Wehnert, N, Whitwell, HJ   +9 more
core   +2 more sources