Results 311 to 320 of about 62,620 (348)

Primary sclerosing cholangitis

The American Journal of Surgery, 1971
Abstract Primary sclerosing cholangitis is an uncommon condition of unknown etiology, presenting extrahepatic biliary obstruction due to a chronic inflammatory obliterative process. Criteria for diagnosis include progressive biliary obstruction due to a chronic inflammatory fibrous process, absence of biliary stones, absence of biliary surgery prior ...
A W, Perry, E, Djang, G, Kafrouni, L G, Ludington   +3 more
openaire   +2 more sources

Primary sclerosing cholangitis

Gastroenterology Nursing, 2007
Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown origin characterized by progressive inflammation, destruction, and fibrosis of the intrahepatic and extrahepatic bile ducts. The disease leads to obliteration of intrahepatic bile ducts and to biliary cirrhosis, end-stage liver disease, and portal hypertension.
A.J. SMALL, N.F. LARUSSO, K.N. LAZARIDIS
openaire   +3 more sources

Primary sclerosing cholangitis

Nature Reviews Disease Primers
Primary sclerosing cholangitis (PSC) is a chronic biliary inflammation associated with periductular fibrosis of the intrahepatic and extrahepatic bile ducts leading to strictures, bacterial cholangitis, decompensated liver disease and need for liver transplantation.
Michael P. Manns, Annika Bergquist, Tom H. Karlsen, Cynthia Levy, Andrew J. Muir, Cyriel Ponsioen, Michael Trauner, Grace Wong, Zobair M. Younossi   +8 more
openaire   +4 more sources

Oral vancomycin is associated with improved inflammatory bowel disease clinical outcomes in primary sclerosing cholangitis‐associated inflammatory bowel disease (PSC‐IBD): A matched analysis from the Paediatric PSC Consortium

Alimentary Pharmacology and Therapeutics
Data on oral vancomycin for primary sclerosing cholangitis (PSC)‐associated inflammatory bowel disease (IBD) are limited.
A. Ricciuto, Kuan Liu, W. El-Matary, M. Amin, A. Amir, Madeleine Aumar, M. Auth, Matthew D. Di Guglielmo, Eleonora Druve Tavares Fagundes, Alexandre Rodrigues Ferreira, K. Furuya, Nitika A Gupta, Stephen L Guthery, S. P. Horslen, Kyle Jensen, B. Kamath, N. Kerkar, B. G. P. Koot, Trevor J. Laborda, Christine K. Lee, K. Loomes, Cara L. Mack, Mercedes Martinez, A. Montano-Loza, Nadia Ovchinsky, A. Papadopoulou, E. Perito, P. Sakthi Sathya, Kathleen B. Schwarz, Uzma Shah, E. Shteyer, Nisreen Soufi, James Patrick Stevens, Amy E Taylor, M. Tessier, P. Valentino, M. Woynarowski, M. Deneau   +37 more
semanticscholar   +1 more source

Primary Sclerosing Cholangitis

Inflammatory Bowel Diseases, 2005
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the intra- and extrahepatic bile ducts. An estimated 80% of patients in North America and Europe have coexistent inflammatory bowel disease (IBD). The underlying pathophysiology of PSC remains poorly understood.
Jayant A, Talwalkar, Keith D, Lindor
openaire   +2 more sources

Primary sclerosing cholangitis

Current Problems in Surgery, 1992
Primary sclerosing cholangitis is a condition of unknown cause. It is recognized by liver dysfunction and its characteristic radiologic appearance, which is related to portal tract inflammation, bile duct proliferation, and periductal fibroses involving small intrahepatic and large extrahepatic ducts.
F M, Martin, J W, Braasch
openaire   +2 more sources

Primary Sclerosing Cholangitis

Archives of Internal Medicine, 1982
Recent investigations have clarified the clinical, radiologic, and pathologic features of primary sclerosing cholangitis, a chronic fibrosing disorder affecting the biliary tree. This progressive, cholestatic biliary disease is diagnosed when an elevated serum alkaline phosphatase level and stricturing and beading of bile ducts on cholangiography are ...
openaire   +2 more sources

Primary Sclerosing Cholangitis

Southern Medical Journal, 1978
Two new cases of primary sclerosing cholangitis with a rapid fatal course, particularly the patient in Case 2, are presented. Primary sclerosing cholangitis is a rare condition of unknown cause presenting with extrahepatic biliary obstruction due to a chronic inflammatory obliterative process with the absence of stones, cancer, or previous biliary ...
M, Maleki, M, Faghihi, M, Golshan
openaire   +2 more sources

Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial.

American Journal of Gastroenterology, 2019
BACKGROUND Primary sclerosing cholangitis (PSC) is a cholestatic liver disease with no effective medical therapies. A perturbation of the gut microbiota has been described in association with PSC, and fecal microbiota transplantation (FMT) has been ...
J. Allegretti, Z. Kassam, Madeline Carrellas, B. Mullish, J. Marchesi, A. Pechlivanis, Mark Smith, Y. Gerardin, Sonia C. Timberlake, D. Pratt, J. Korzenik   +10 more
semanticscholar   +1 more source

Simtuzumab for Primary Sclerosing Cholangitis: Phase 2 Study Results With Insights on the Natural History of the Disease

Hepatology, 2019
Lysyl oxidase like‐2 (LOXL2) plays a central role in fibrogenesis and is elevated in the serum and liver of patients with primary sclerosing cholangitis (PSC).
A. Muir, C. Levy, H. Janssen, A. Montaño-Loza, M. Shiffman, S. Caldwell, V. Luketic, D. Ding, C. Jia, B. McColgan, J. Mchutchison, G. Mani Subramanian, R. Myers, M. Manns, R. Chapman, N. Afdhal, Z. Goodman, B. Eksteen, C. Bowlus   +18 more
semanticscholar   +1 more source