Results 71 to 80 of about 62,620 (348)

Association of ulcerative colitis, celiac disease, primary sclerosing cholangitis and liver cirrhosis in a young male

JGH Open, 2023
Inflammatory bowel diseases (IBD), including ulcerative colitis, are chronic autoimmune conditions characterized by inflammation of the digestive system.
Ahmad N. Alkhaledi, Isra Jadaan, Mohamad Zaher Sharfo, Tala Faysal, Yazane Abdallah, Ahmad Alhaj Ali   +5 more
doaj   +1 more source

Primary sclerosing cholangitis: a pre-malignant condition [PDF]

, 2017
Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease with no known cure. It is a serious condition, and diagnosis comes with an increased risk of developing cancer of the gallbladder, bile ducts or liver. Symptoms can
Mortimore, Gerri
core   +2 more sources

Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci

Nature Communications
Genome-wide association studies of primary sclerosing cholangitis have identified 23 susceptibility loci. The majority of these loci reside in non-coding regions of the genome and are thought to exert their effect by perturbing the regulation of nearby ...
Elizabeth C. Goode, Laura Fachal, Nikolaos Panousis, Loukas Moutsianas, Rebecca E. McIntyre, Benjamin Yu Hang Bai, Norihito Kawasaki, Alexandra Wittmann, Tim Raine, Simon M. Rushbrook, Carl A. Anderson   +10 more
doaj   +1 more source

Etiology, Epidemiology, and Therapeutic Approaches for Primary Sclerosing Cholangitis in the Context of Concurrent Non-specific Inflammatory Bowel Diseases

Journal of Education, Health and Sport
Introduction: Primary sclerosing cholangitis (PSC) is a chronic, idiopathic disease characterized by persistent and progressive inflammation of the intrahepatic and/or extrahepatic bile ducts. This leads to fibrosis, cholestatic complications, and liver
Anna Olszewska, Karolina Matyja, Aleksandra Berner, Katarzyna Stencel, Karina Stelmaszak, Klaudia Marczyk, Paulina Polak, Maciej Pękała, Monika Polaszek, Marta Bogowska   +9 more
doaj   +1 more source

Efficacy of hepatic transplantation in patients with primary sclerosing cholangitis [PDF]

, 1993
Controlled trials to assess the therapeutic benefit of orthotopic hepatic transplantation (OHTx) for primary sclerosing cholangitis (PSC) cannot be justified in view of improvement of patient survival after this operation since 1981.
Abu-Elmagd, KM, Demetris, AJ, Dickson, ER, Fung, JJ, Krom, RAF, Langworthy, AL, Malinchoc, M, Murtaugh, PA, Starzl, TE, Van Thiel, DH   +9 more
core  

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis [PDF]

, 2011
Background/Aims: The chromosome 4q27 region harboring IL2 and IL21 is an established risk locus for ulcerative colitis (UC) and various other autoimmune diseases.
Albers HM, Barrett JC, Barrett JC, Bergquist A, Bergquist A, Bo X, Burkhard Göke, Chapman R, Chen B, Christian Rust, Daha NA, Fay MP, Festen EA, Gerald Ulrich Denk, Gershwin ME, Gershwin ME, Glas J, Glas J, Henckaerts L, Hinks A, Hirschfield GM, Johannes Stallhofer, Jürgen Glas, Kaplan MM, Karlsen TH, Laurence A, Li Y, Liu Y, Loftus, Loftus EV, Maiti AK, Malek TR, Marquez A, McGuire HM, Peluso I, Rüdiger Paul Laubender, Saarinen S, Sadlack B, Saich R, Saraiva M, Sawalha AH, Sgouroudis E, Stephan Brand, Thomas Pusl, Todd JA, van Heel DA, Weismuller TJ, Yamanouchi J, Yang L, Zheng SG, Zhernakova A, Zhernakova A   +51 more
core   +1 more source

MAIT cells come to the rescue in cancer immunotherapy? [PDF]

, 2020
Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk, Venken, Koen, Łukasik, Zuzanna   +2 more
core   +2 more sources

Bile Acid Profiles in Primary Sclerosing Cholangitis and Their Ability to Predict Hepatic Decompensation

Hepatology, 2020
Altered bile acid (BA) homeostasis is an intrinsic facet of cholestatic liver diseases, but clinical usefulness of plasma BA assessment in primary sclerosing cholangitis (PSC) remains understudied.
O. Mousa, B. Juran, Bryan M McCauley, M. Vesterhus, T. Folseraas, Coleman T. Turgeon, A. Ali, E. Schlicht, E. Atkinson, Chang Hu, D. Harnois, E. Carey, A. Gossard, D. Oglesbee, J. Eaton, N. LaRusso, G. Gores, T. Karlsen, K. Lazaridis   +18 more
semanticscholar   +1 more source

Primary sclerosing cholangitis

Annual Review of Medicine, 1993
Primary sclerosing cholangitis (PSC) is an inflammatory disease of unknown etiology. It affects the biliary system and is characterized by fibrosis and progressive obliteration of extrahepatic and intrahepatic bile ducts. Its frequent coexistence with antibody-mediated diseases, certain human leukocyte antigens, and altered lymphocyte mechanisms ...
openaire   +2 more sources

Serum Bile Acids Are Useful Indicators of Intrahepatic Recurrence After Initial Curative Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Bile acids accumulation in hepatocytes causes liver damage and contributes to the development of hepatocellular carcinoma. However, the association between serum bile acid levels and postoperative intrahepatic recurrence in hepatocellular carcinoma remains unclear.
Tomoaki Bekki, Masahiro Ohira, Yuki Imaoka, Seiichi Simizu, Tomoyuki Abe, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Hideki Ohdan   +9 more
wiley   +1 more source