Results 71 to 80 of about 8,186,425 (263)

Classification rule for ten year MACE Risk in primary care tarragona older adults with type2 diabetes: a CHAID decision-tree analysis [PDF]

CHAID; Decision tree; Diabetes; MACECHAID; Árbol de decisión; Diabetes; MACECHAID; Decision tree; Diabetes; MACECardiovascular disease is the leading cause of mortality among individuals with Type 2 Diabetes Mellitus (T2DM). This study developed a simple
Vila-Corcoles, Angel, de diego cabanes, cinta, Ribas Seguí, Domingo J, Forcadell, Mª José, Ochoa-Gondar, Olga, SATUÉ-GRACIA, Eva, Martín Luján, Francisco M   +6 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Stiffness and strength of shear diaphragms used for stability bracing of slender beams

, 2014
Structural Stability Research Council Annual Stability Conference 2014, SSRC 2014; Toronto, ON; Canada; 25 March 2014 through 28 March 2014Light gage metal decking is often used in structures as concrete deck formwork, roof cladding or siding.
Vardaroğlu, Mustafa, Eğilmez, Oğuz Özgür, Akbaba, Andaç   +2 more
core   +1 more source

Evaluation of the Relationship between the Bone Density Estimated by Cone-Beam Computed Tomography and the Primary Stability of Dental Implants

پزشکی بالینی ابن سینا, 2013
Introduction & Objective: Study of bone quality before treatment is very important. The aims of this study were to assess bone quality with density values obtained by cone-beam computed tomography (CBCT) and to determine the correlations between bone ...
Bijan Heidari, Saman Fallahi, Farnaz Firouz, Javad Faradmal, Sahar Mosavi, Meysam Khalesi, Hafez Ariyamanesh   +6 more
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Parkside Primary School PTA letter

, 1996
Letter to parents of a resolution taken at a meeting of the Parkside Primary School PTA, held at the Muslim Movement Hall, to oppose the department's envisaged rationalisation ...
Parent Teacher Assocation, Parkside Primary School
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source