Results 181 to 190 of about 150,567 (245)

Mitochondrial DNA Fragment Dynamics in Acute and Chronic Human Immunodeficiency Virus: Insights From Human and Nonhuman Primate Models. [PDF]

J Infect Dis
Sun J, Nidadavolu LS, Hsu HY, Rajagopal RG, Astemborski J, Wu Y, Jiang Y, Sacha JB, Kievit P, Jamieson BD, Roberts CT, Kirk GD, Brown TT, Abadir PM.   +13 more
europepmc   +1 more source

Targeting Hsp90 with cemdomespib reduces seizure burden and alters disease course in preclinical epilepsy models

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a chronic neurological disorder characterized by recurrent seizures and frequent cognitive and psychiatric comorbidities. Although current antiseizure medications provide symptomatic relief, they fail to prevent or modify epileptogenesis.
Yara Sheeni, Prince Kumar Singh, Sereen Sandouka, Taige Zhang, Alina Nemirovski, Aseel Saadi, Rhoda Olowe Taiwo, Matthew C. Walker, Tawfeeq Shekh‐Ahmad   +8 more
wiley   +1 more source

A reservoir at the gates: nonhuman mammalian hosts for human schistosomiasis in western Africa and the critical challenge for elimination. [PDF]

Infect Dis Poverty
Sanogo B, Echoru I, Jones C, Butala C, Lin D, Maiga H, Sámano-Sánchez H, Sacko M, Kassegne K, Welburn SC.   +9 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

sedimix: a workflow for the analysis of hominin nuclear DNA sequences from sediments. [PDF]

Bioinformatics
Xu J, Zavala EI, Moorjani P.
europepmc   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

Genetic legacy and recent cross of two ancient lineages underlie the rebound of the world's rarest primate. [PDF]

Sci Adv
Hou X, Pan S, Xu J, Hu L, He W, Liu X, Huang S, Gu Z, Lin Z, Chen Y, Li W, Luo T, Zhao X, Dai Q, Cao P, Liu F, Feng X, Fu Q, Zhou J, Wang J, Zhan X.   +20 more
europepmc   +1 more source

Convergent evolution of metabolic functions: Evidence from the gut microbiomes of humans and dogs

iMetaOmics, EarlyView.
Dogs have undergone convergent evolution in their genome with humans in long‐term co‐living. Studies have shown that the gut microbiomes of dogs exhibit greater similarity to those of humans compared to mice and pigs. In our study, we first compared the gut microbiomes of macaques, three dog groups, and two wolf groups to those in humans.
Xiaoyang Wang, Lei Zhu, Yue Lan, Guimei Li, Tong Zhou, Qingguo Huang, Tifei Yuan, Chen Tian, Zhenxin Fan, Zhigang Zhang, Guo‐Dong Wang   +10 more
wiley   +1 more source

Engraftment of gene-edited hematopoietic stem cells after antibody-drug conjugate conditioning in nonhuman primates. [PDF]

Blood Adv
Murray J, Einhaus T, Radtke S, Bar KJ, Peterson CW, Kiem HP.   +5 more
europepmc   +1 more source

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, EarlyView.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source