Results 321 to 330 of about 578,331 (406)

Extracellular Origins of Cognition: Lessons from Primate Neocortical ECM. [PDF]

Proteomics
Stern S.
europepmc   +1 more source

Pregnenolone Reduces L‐Dopa‐Induced Dyskinesias in Female Parkinsonian Monkeys

Movement Disorders, EarlyView.
Pregnenolone is the first neurosteroid synthesized from cholesterol in the brain. Ovariectomized female monkeys were tested as a model of women in menopause. They were lesioned with MPTP modeling Parkinson's disease and treated with levodopa (L‐dopa) to induce dyskinesias.
Mélanie Bourque, Marc Morissette, Marco Bortolato, Roberto Frau, Manolo Carta, Thérèse Di Paolo   +5 more
wiley   +1 more source

Multiparous and primiparous mothers partially differ in how they allocate maternal behaviour in captive western lowland gorillas (Gorilla gorilla gorilla). [PDF]

Primates
Amici F, Pinnecke JA, Prieur J, Liebal K.   +3 more
europepmc   +1 more source

Anti‐Neuroinflammatory and Anti‐Inflammatory Effects of the NLRP3 Inhibitor NT‐0796 in Subjects with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Inhibition of Nod‐like receptor protein 3 (NLRP3) inflammasome within the central nervous system (CNS) is a promising therapeutic target for the treatment of Parkinson's disease (PD). Objectives This phase 1b open‐label study was conducted in elderly healthy volunteers (HV) and PD patients.
Nicholas Clarke, Peter Thornton, Valérie Reader, Nicola Lindsay, Zsofia Digby, Bianca Mullen, Michelle Gorman, Eric Jacobson, Grant Langdon, Hilary Johnstone, Alistair Wheeler, Alan P. Watt   +11 more
wiley   +1 more source

Intramuscular DNA vaccine provides protection in non-human primate and mouse models of SARS-CoV-2. [PDF]

Front Immunol
Sood S, Gary EN, Matar M, Kim J, Hojecki CE, Warner B, Vendramelli R, Truong T, Smith A, Rice J, Sparks J, DeSalvo M, Henderson J, Rogers JA, Sharma A, Pessaint L, Iavarone CA, Kobasa D, Boyer JD, Lindborg S, Anwer K.   +20 more
europepmc   +1 more source

Grape Seed Proanthocyanidins: A Potential Microbiome‐Targeted Intervention for Healthy Aging in Rats

Molecular Nutrition &Food Research, EarlyView.
Grape seed proanthocyanidin extract (GSPE) promotes a healthier gut phenotype in aged rats. Aging alters gut microbiota composition, increases inflammation, and compromises intestinal barrier function. This study shows that short‐term GSPE treatment in aged rats partially restores microbial diversity toward a youthful profile, modulates mucus‐related ...
Marta Sierra‐Cruz, Adrià Vilalta, Alba Miguéns‐Gómez, Harry Park, Esther Rodríguez‐Gallego, Maria Teresa Blay, Anna Ardévol, Montserrat Pinent, Jacques Behmoaras, Raúl Beltrán‐Debón, Ximena Terra   +10 more
wiley   +1 more source

Landscape of A-I RNA editing in mouse, pig, macaque, and human brains. [PDF]

Nucleic Acids Res
Li C, Lv W, He Z, Pan X, Zeng Y, Mulder J, Sjöstedt E, Huang Z, Liu W, Xu L, Eisenberg E, Lin L, Hansen JB, Huang J, Luo Y.   +14 more
europepmc   +1 more source

Impact of Nutrition on Sphingolipid‐Regulated Physiology: A Review

Molecular Nutrition &Food Research, EarlyView.
Sphingolipids (SLs) play a role in multiple, if not all physiological processes. This review summarizes the current knowledge on SLs and their role in (patho‐) physiological processes with special regard to dietary and transgenerational effects. Image was created with BioRender.com.
Jonas Voß, Thorsten Hornemann, Bengt‐Frederik Belgardt   +2 more
wiley   +1 more source

Pre-clinical xenotransplantation: physiology and pharmacy in human decedent and non-human primate models. [PDF]

Front Transplant
Anderson DJ, Locke JE.
europepmc   +1 more source

Effects of management strategies on the survival probability of a small remnant population of mouse lemurs

Oikos, EarlyView.
Multiple management strategies have been put in place in Madagascar to slow down biodiversity loss, but evidence for their effectiveness remains scarce. Using a long‐term monitoring dataset and a custom‐built capture–mark–recapture model, we evaluated the effect of a protected area and translocations on the survival of mouse lemurs Microcebus murinus ...
Andrea F. Vallejo‐Vargas, Pierre Dupont, S. Jacques Rakotondranary, Ernest Refaly, Jean‐Baptiste Ramanamanjato, Faly Randriatafika, Cedric Tsagnangara, B. Karina Montero   +7 more
wiley   +1 more source