Results 51 to 60 of about 823,935 (279)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Polynomial behavior of the Honda formal group law

, 2016
This note provides the calculation of the formal group law $F(x,y)$ in modulo $p$ Morava $K$-theory at prime $p$ and $s>1$ as an element in $K(s)^*[x][[y]]$ and one application to relevant examples.Comment: 4 pages, submitted in Journal of Homotopy and ...
Bakuradze, Malkhaz
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A new characterization of Chevalley groups $\mathrm{G}_2(3^n)$ by the order of the group and the number of elements with the same order [PDF]

AUT Journal of Mathematics and Computing
In this paper, we prove that Chevalley groups $G_2(q)$, where $q=3^n$ and $q^2+q+1$ is a prime number, can be uniquely determined by the order of group and the number of elements with the same order.
Behnam Ebrahimzadeh, Hamid Shahbandarzadeh   +1 more
doaj   +1 more source

Resolvable Mendelsohn designs and finite Frobenius groups

, 2018
We prove the existence and give constructions of a $(p(k)-1)$-fold perfect resolvable $(v, k, 1)$-Mendelsohn design for any integers $v > k \ge 2$ with $v \equiv 1 \mod k$ such that there exists a finite Frobenius group whose kernel $K$ has order $v$ and
Hsu, D. F., Zhou, Sanming
core   +1 more source

Vanishing elements of prime power order

Communications in Algebra
An element $x$ in a finite group $G$ is said to be \textit{vanishing} if some (complex) irreducible character of $G$ takes value $0$ at $x$. In this article, we prove that every non-abelian finite simple group, except $\mathrm{SL}_2(4)$ and $\mathrm{SL}_2(8)$, contains a vanishing element \textit{of prime power order} whose conjugacy class size is ...
Arora, Sonakshee, Kitture, Rahul Dattatraya   +1 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Elliptic elements in a Weyl group: a homogeneity property

, 2010
Let G be a reductive group over an algebraically closed field whose characteristic is not a bad prime for G. Let w be an elliptic element of the Weyl group which has minimal length in its conjugacy class.
Lusztig, G.
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source