Disrupting pegRNA intramolecular complementarity via PBS and spacer sequence alterations can enhance prime editing efficiency. [PDF]
Biczók Z +10 more
europepmc +1 more source
Machine Learning‐Assisted Inverse Design of Soft and Multifunctional Hybrid Liquid Metal Composites
A machine learning framework is presented for inverse design of synthesizable multifunctional composites containing both liquid metal and solid inclusions. By integrating physics‐based modeling, data‐driven prediction, and Bayesian optimization, the approach enables intelligent design of experiments to identify optimal compositions and realize these ...
Lijun Zhou +5 more
wiley +1 more source
Comparison of Vaccine Platforms for Machupo Virus. [PDF]
Erickson R +6 more
europepmc +1 more source
Titanium Suboxides Responsible for Electronic Anomaly Near Room Temperature in the Ti3C2Tx MXene
Our multi‐technique study reveals that the near‐room‐temperature anomaly in Ti3C2Tx MXene is linked to titanium suboxide nanodomains, including Ti3O5, embedded within the MXene host. Their temperature‐driven transformation provides an alternative explanation to solvent‐ and swelling‐based models and offers new insight into the thermally activated ...
Bence G. Márkus +8 more
wiley +1 more source
Viral vector-free generation of orthogonal IL-2-responsive CAR T cells through gene editing of IL-2 and its receptor. [PDF]
Zhang Q +20 more
europepmc +1 more source
When hydrated zinc ions are deposited onto Cu substrates at practical current densities, the modified Cu enables simultaneously compact zinc growth and suppressed hydrogen evolution. This regulatory effect originates from the superior adsorption of the modified Cu interface, which enhances zincophilicity and the hydrogen desorption barrier, thereby ...
Zhe Zhu +8 more
wiley +1 more source
Influence of the administration route and dose on the expression and antibody responses of a reporter and avian influenza self-amplifying mRNA vaccine in poultry. [PDF]
Snoeck J +4 more
europepmc +1 more source
Exploring Pb‐Chelation Chemistry in the Crystallization Dynamics of Halide Perovskites
A mechanism of how Pb‐chelation chemistry governs coordination geometry and initial nucleation behavior at the precursor level of halide perovskite, by regulating the deprotonation state of a chelating additive, is elucidated. This allows for innovative reaction‐system design principles that promote coherent growth while suppressing defect formation in
Byeong Jun Kim +13 more
wiley +1 more source
The Existential Risks of Nuclear Weapons: A Role for Ethics and Emotions. [PDF]
Roeser S.
europepmc +1 more source

