Results 171 to 180 of about 612,378 (298)

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

CRISPR Gene Tagging for Illuminating Endogenous Protein Dynamics. [PDF]

Int J Mol Sci
Afifi N, Colussi D, Perez-Leal O.
europepmc   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Labeling genetically modified food in India: Economic consequences in four marketing channels [PDF]

In 2006, India proposed a draft rule requiring the labeling of all genetically modified (GM) foods and products derived thereof. In this paper, we use primary and secondary market data to assess the economic implications of introducing such a mandatory ...
Gruère, Guillaume, Bansal, Sangeeta
core  

Orthogonal DNA barcoding enables subpopulation-resolved extracellular vesicle miRNA profiling. [PDF]

Sci Adv
Zhang Y, Zhu Y, Zhang Y, Peng S, Wu D, Li W, Ji T, Chen S, Lin Y, Yang H, Guo Y, Li B, Liu C, Situ B, Yan X, Zheng L.   +15 more
europepmc   +1 more source

Employment Trajectories of Patients With Systemic Lupus Erythematosus and Factors Driving Transitions Between States

Arthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) significantly impacts employment capacity. This study aimed to investigate the impact of burden of disease activity, damage, and treatment on employment outcomes and transitions in patients with SLE. Methods Using data from a single center, we analyzed employment transitions, adjusted mean disease activity ...
Javier Mencia‐Ledo, Zahi Touma, Laura Whittall Garcia, Dafna D. Gladman, Behdin Nowrouzi‐Kia   +4 more
wiley   +1 more source

Should the United States Regulate Mandatory Labeling for Genetically Modified Foods? [PDF]

Public debate continues over whether the United States should regulate genetically modified (GM) foods by imposing a mandatory labeling policy. This paper develops a model that shows that a voluntary GM-labeling policy results in higher welfare than a ...
Huffman, Wallace, Tegene, Abebayehu, Rousu, Matthew, Shogren, Jason F.   +3 more
core  

Beyond GMOs: transgene-free gene-edited crops for global food security. [PDF]

Front Plant Sci
Ahmad A, Faheem M, Ijaz A, Niamat A, Huda NU, Munir A, Siddique S, Asaf S, Khan H, Munawar N, Al Harrasi A.   +10 more
europepmc   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Market Differentiation Potential of Country-of-origin, Quality and Traceability Labeling [PDF]

Product labeling has gained considerable attention recently, as a means to both provide product-specific information and reduce quality uncertainty faced by consumers, as well as from a regulatory point of view.
Verbeke, Wim, Roosen, Jutta
core