Results 101 to 110 of about 57,355 (195)

Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy. [PDF]

J Clin Invest
Mix MR, Sievers CM, Hassert M, Kannan SK, Pewe LL, Huang SC, He R, Fain CE, Heidarian M, Hancox LS, Arumugam SA, Beltz TG, Jin F, Johnson AJ, Carter CS, Butler NS, Salem AK, Badovinac VP, Harty JT.   +18 more
europepmc   +1 more source

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

A stabilized MERS-CoV spike ferritin nanoparticle vaccine elicits robust and protective neutralizing antibody responses. [PDF]

Nat Commun
Powell AE, Caruso H, Park S, Chen JL, O'Rear J, Ferrer BJ, Stieh DJ, Weiss AM, Belnap DM, Walker A, Bruening A, Hartwig A, Sprouse KR, Addetia A, Alshukairi AN, Ahyong V, Dougherty CS, Veesler D, Bowen R, Ledgerwood JE, Kay MS, Weidenbacher PA, Palanski BA.   +22 more
europepmc   +1 more source

Ductility Tuning via Cluster Network Characteristics of Porous Components

Advanced Materials Technologies, EarlyView.
Network optimization via cluster characteristics induced by interaction of stress concentration is proposed, demonstrating increased cluster size and dispersion in non‐uniform porous components. The optimized structures exhibit, for the first time, that enhanced ductility and damage progression is controllable through zigzag cluster network designed by
Ryota Toyoba, Yuichi Otsuka, Ian J Davies, Naritoshi Aoyagi, Yukio Miyashita   +4 more
wiley   +1 more source

Treatment of a metabolic liver disease in mice with a transient prime editing approach. [PDF]

Nat Biomed Eng
Rothgangl T, Tálas A, Ioannidi EI, Weber Y, Böck D, Matsushita M, Villiger EA, Schmidheini L, Moon WJ, Lin PJC, Fan SHY, Marquart KF, Schwerdel C, Rimann N, Faccin E, Villiger L, Muramatsu H, Vadovics M, Cremonesi A, Kulcsár PI, Thöny B, Kopf M, Häberle J, Pardi N, Tam YK, Schwank G.   +25 more
europepmc   +1 more source

Large‐Scale and Cost‐Effective Fabrication of Ultra‐Thin, Biodegradable Microelectrode Arrays and Pressure Sensors Using Laser Micromachining

Advanced Materials Technologies, EarlyView.
A mask‐free and cost‐effective UV‐pico‐second laser‐based microfabrication method is proposed to fabricate large‐area biodegradable microelectrode arrays and pressure sensors. These devices demonstrate low impedance, good conformability, excellent biocompatibility, and rapid degradation, providing a new route for next‐generation transient electronics ...
Bhavani Prasad Yalagala, Asfand Tanwear, María Cerezo‐Sánchez, Hossein Parvizi, Morteza Amjadi, Hadi Heidari   +5 more
wiley   +1 more source

Combining label-free Raman spectroscopy and machine learning to identify early biomarkers of COVID-19 disease severity and mortality. [PDF]

J Biomed Opt
Heidarifard M, Ember K, Dallaire F, Brunet-Ratnasingham E, Chen Y, Ksantini N, Mahfoud M, Sheehy G, Soudeyns H, Jouvet P, Tse SM, Quach C, Richards B, Kaufmann DE, Leblond F, Dehaes M.   +15 more
europepmc   +1 more source

Chemically Doped Conductive Polymers for Wearable Health Monitoring

Advanced Materials Technologies, EarlyView.
Among conductive polymers, poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), polyaniline (PANI), and polypyrrole (PPy) are the most studied and applied. Chemical doping significantly boosts intrinsic conductivity and mechanical robustness.
Mengdi Zuo, Jian Song, Hong Hu, Le Zheng, Lei Zhang, Charles H. Lawrie   +5 more
wiley   +1 more source

Ultrasound-activated piezoelectric Silk-PVDF hydrogel reprograms the osteoimmune microenvironment via NRF2 signaling for accelerated bone regeneration. [PDF]

Mater Today Bio
Mo G, Qing L, Zhang C, Huang L, Yan H, Lu S, Zhang Y, Chen W, Xiang X, Wang N, Han G, Li Y, Jiang L, Zhang J.   +13 more
europepmc   +1 more source

Cap‐oPMN: Oral Inflammatory Load Quantification Using Capillary Microfluidics and Automated Image Processing

Advanced Materials Technologies, EarlyView.
ABSTRACT Quantifying oral polymorphonuclear neutrophils (oPMNs) is a clinically validated approach for assessing periodontal inflammation. However, current methods, such as manual hemocytometry and flow cytometry, are time‐consuming (>3 h), require invasive sampling, and depend on staining and complex instrumentation, making them unsuitable for point ...
Mohsen Hassani, Azam Zare, Fatemeh Soheili, S. M. Mahdi H. Daneshvar, Mahdi Amrollahi Biouki, Yasaman Tahernezhad, Chunxiang Sun, Michael Glogauer, Ebrahim Ghafar‐Zadeh, Amir Sanati‐Nezhad   +9 more
wiley   +1 more source