Detecting single molecules on large interfaces is challenging due to minimal perturbations on the sensing surface. Some biological systems achieve this feat using amplification mechanisms, but their molecular foundations remain unclear. To investigate, a Design of Experiments (DoE) approach examines how pH and ionic strength in conditioning solutions ...
Michele Catacchio+9 more
wiley +1 more source
An mRNA vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses confers cross-protection against influenza a viruses in adult and aged mice. [PDF]
Xu L+8 more
europepmc +1 more source
Herein, polymer nanogels with a reporting interface for albumin are synthesized through reversible addition–fragmentation chain transfer (RAFT) precipitation polymerization of di(ethylene glycol) methyl ether methacrylate and N,N’‐methylenebis(acrylamide) using a poly(2‐methacryloyloxyethyl phosphorylcholine) macro‐RAFT agent, followed by dansyl ...
Yukiya Kitayama+2 more
wiley +1 more source
Intranasal prime-boost RNA vaccination elicits potent T cell response for lung cancer therapy. [PDF]
Li H+6 more
europepmc +1 more source
ZIF‐8@PAN nanofiber membrane with a core‐shell structure is produced via coaxial electrospinning for removing tetracycline antibiotics. The adsorption behavior under different conditions, kinetics, thermodynamics, and isotherm are studied. Adsorption mechanisms include electrostatic interactions, coordination, hydrogen bonding, and π–π interactions ...
Pu Wang+5 more
wiley +1 more source
Targeting Respiratory Viruses: The Efficacy of Intranasal mRNA Vaccination in Generating Protective Mucosal and Systemic Immunity Against Influenza A (H1N1). [PDF]
Yahyaei S+6 more
europepmc +1 more source
Biocompatibility and Long‐Term Stability of DNA‐Based Organic Mixed Conductors for Bioelectronics
The biocompatibility and long‐term stability of DNA‐based mixed ionic‐electronic conductors are investigated. In vitro cytotoxicity and cell viability are assessed using flow cytometry assay on primary mouse fibroblasts cultures. The biocomposites are integrated into organic electrochemical transistors (OECTs) to determine the stability of their ...
Sarka Hradilova+7 more
wiley +1 more source
Milk Exosome-Based Delivery System for Probiotic Encapsulation That Enhances the Gastrointestinal Resistance and Adhesion of Probiotics. [PDF]
Hao L+6 more
europepmc +1 more source
This study presents a platform for simultaneous monitoring and electrical control of cellular responses at the cell–electrode interface. The platform delivers tunable yet uniform electrical cues to cells, revealing that optimal electrical stimulation (ES) conditions vary across cell types.
Khandoker Asiqur Rahaman+7 more
wiley +1 more source
Co-Delivery of Dacarbazine and miRNA 34a Combinations to Synergistically Improve Malignant Melanoma Treatments. [PDF]
Ding B+9 more
europepmc +1 more source