Results 131 to 140 of about 626,535 (304)

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

Nature Medicine, 2015
Siu Ling Wong, M. Demers, K. Martinod, M. Gallant, Yanming Wang, Allison B Goldfine, C. R. Kahn, Denisa D Wagner   +7 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Glutathione Primes T Cell Metabolism for Inflammation

Immunity, 2017
T. Mak, Melanie Grusdat, G. Duncan, Catherine Dostert, Yannic Nonnenmacher, M. Cox, Carole Binsfeld, Zhenyue Hao, A. Brüstle, M. Itsumi, Christian Jäger, Ying Chen, Olaf Pinkenburg, Bärbel Camara, M. Ollert, C. Bindslev‐Jensen, V. Vasiliou, C. Gorrini, P. Lang, M. Lohoff, I. Harris, Karsten Hiller, D. Brenner   +22 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Nature, 2015
Lin Zhang, Siyuan Zhang, Jun Yao, Frank J. Lowery, Qingling Zhang, Wen-Chien Huang, Ping Li, Min Li, Xiao Wang, Chenyu Zhang, Hai Wang, K. Ellis, Mujeeb R. Cheerathodi, J. McCarty, D. Palmieri, J. Saunus, S. Lakhani, Suyun Huang, A. Sahin, K. Aldape, P. Steeg, Dihua Yu   +21 more
semanticscholar   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

On properties of the numbers coprime with the primes up to p_n

Le Matematiche, 2006
In this paper we investigate about the effective distribution of the numbers coprime with the primes up to p_n . More precisely we prove that these numbers form a periodically monotone sequence . Then we examine some properties of this sequence which, in
Giovanni Fiorito
doaj  

Efficient organic pollutant mineralization via PMS-sonophotocatalysis with doped-ZnO-CNT aerogels

Applied Catalysis O: Open
This study investigates some characteristics of multi-walled carbon nanotube (MWCNT)-integrated zinc oxide (ZnO)-based aerogels doped with aluminum (A4ZO), gallium (G5ZO), and indium (I1ZO).
Queralt Bautista, Majdi Benamara, Shanyu Zhao, Elvira Gómez, Albert Serrà   +4 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source