Results 71 to 80 of about 12,311 (256)

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

open access: yesAdvanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li   +5 more
wiley   +1 more source

Optimizing Agriculture: A Review of Chemical Priming in Crop Production

open access: yesInternational Journal of Plant & Soil Science
Agricultural productivity faces increasing challenges due to climate change, soil degradation, and the need for sustainable practices. Chemical priming, a technique involving the pre-treatment of seeds or plants with specific compounds, has emerged as a promising approach to enhance crop resilience, productivity, and stress tolerance.
Adil Rahim Margay, Arif Hassan
openaire   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

open access: yesAdvanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He   +17 more
wiley   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

open access: yesAdvanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao   +16 more
wiley   +1 more source

Effect of Seed Priming with Gibberellic Acid and Salicylic Acid on Germination Characteristic and Seed and Seedlings Physiological Quality of Lentil (Lens culinaris)

open access: yesپژوهش‌های بذر ایران, 2016
One of the important strategies for increasing germination speed and germination percentage, to produce high-quality seedling and plant optimal establishment is seed priming.
Mohsen Azarnia   +4 more
doaj   +2 more sources

Mass Spectrometry Imaging‐Assisted Discovery of Gallotannin Biosynthetic Genes in the Root of Paeonia suffruticosa

open access: yesAdvanced Science, EarlyView.
An integrated approach combining mass spectrometry imaging, transcriptomics, and phylogenetic analysis facilitated the efficient identification of genes involved in gallotannin biosynthesis in Paeonia suffruticosa. As a result, a key UGT and several SCPL acyltransferases responsible for biosynthesizing pentagalloylglucose were successfully identified ...
Yushi Liu   +4 more
wiley   +1 more source

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

open access: yesAdvanced Science, EarlyView.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li   +7 more
wiley   +1 more source

Alleviating Salt Stress in Tomatoes through Seed Priming with Polyethylene Glycol and Sodium Chloride Combination

open access: yesStresses
Tomato cultivation grapples with salt stress, disrupting growth parameters and physiological processes. High salinity levels induce osmotic stress, impacting cellular integrity and hindering metabolic activities. Salt accumulation at the root zone alters
Nasratullah Habibi   +3 more
doaj   +1 more source

A review on seed priming to combat climate variability in agriculture

open access: yesArchives of Agriculture and Environmental Science
Global agriculture faces immense challenges due to climate change, which causes unpredictable weather patterns, decreased agricultural productivity, and decreased food security. Seed priming is critical in combating climate variability because it has emerged as a promising method for improving seed germination and agricultural resilience.
Rawal, Janak Singh   +2 more
openaire   +2 more sources

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