Solvent-Controlled Chemoselectivity in Brønsted Acidic Deep Eutectic Mixtures: A Metal-Free One-Pot Cascade Meyer-Schuster/C-P Bond Formation. [PDF]
ChemSusChemBrønsted Acidic Deep Eutectic Solvents (BADESs, acting as solvent, promoter, and chemoselectivity controller) based on choline chloride (ChCl) and p‐toluenesulfonic acid (p‐TSA·H2O) enable one‐pot cascade, metal‐free Meyer‐Schuster/C‐P (and C‐Cl) tandem process. Variations in the ChCl:p‐TSA·H2O ratios switches chemoselectivity, affording α‐hydroxy or α‐
Morís-Menéndez G +4 more
europepmc +2 more sources
The Flavonoids Daidzein and Genistein Induce Wall-Deficient Cell Formation in Streptomyces coelicolor Under Hyperosmotic Stress. [PDF]
Microb BiotechnolPlant‐derived isoflavones (daidzein and genistein) function as chemical signals that induce stress‐dependent formation of wall‐deficient cells (S‐cells) in Streptomyces coelicolor. ABSTRACT Streptomycetes exhibit a complex multicellular life cycle, including programmed cell death and hyphal differentiation, and can generate extracellular vesicles and ...
Valdés-Chiara P +3 more
europepmc +2 more sources
PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/HIF2α activation, lipid metabolism rewiring, and ferroptosis evasion [PDF]
Cell Death and DiseaseClear cell renal cell carcinoma (ccRCC) remains a major clinical challenge due to its high metastatic potential and limited treatment options. Here, we identified PCDHGC3 as a critical tumor suppressor, whose downregulation drives ccRCC aggressiveness ...
Lucía Celada +11 more
doaj +2 more sources
CDK7-targeted therapy effectively disrupts cell cycle progression and oncogenic signaling in head and neck cancer [PDF]
Signal Transduction and Targeted TherapyHead and neck squamous cell carcinoma (HNSCC) remains a prevalent and aggressive malignancy, characterized by a lack of targeted therapies and limited clinical benefits.
María Otero-Rosales +20 more
doaj +2 more sources
Association of Chromosome 3p21.32 Haplotype Blocks Introgressed from Neanderthals with Critical COVID-19 in a Spanish Cohort [PDF]
LifeBackground: Human chromosome 3p21.31 variants introgressed from Neanderthals have been associated with a higher risk of developing a severe form of COVID-19. These Neanderthal DNA variants would regulate the expression of several genes, including LZTFL1 (
Daniel Vázquez-Coto +11 more
doaj +2 more sources
Especialistas en el ejército romano. La función militar de los frumentarii durante el Principado
Studia Historica: Historia Antigua, 2021 Este artículo ofrece una perspectiva poco explorada sobre las funciones y evolución de un cuerpo especial perteneciente al ejército romano, los frumentarii.
Miguel Pablo Sancho Gómez
doaj +1 more source
Las funciones institucionales de las mujeres de la familia de Augusto: Octavia, Livia y Julia
Lucentum, 2022 El presente artículo pretende ofrecer una visión sobre el papel institucional desarrollado por las principales mujeres de la familia de Augusto. De esta forma nos proponemos entender la forma en que el “cargo” de emperatriz romana se comienza a perfilar ...
Helena López Gómez
doaj +1 more source
Crónica legislativa de Asturias. Segundo semestre de 2021
Revista de Llengua i Dret - Journal of Language and Law, 2022 Esta crónica presenta la nueva normativa lingüística en la Comunidad Autónoma del Principado de Asturias durante el segundo semestre de 2021, con especial atención a las negociaciones frustradas para reformar el Estatuto de Autonomía del Principado de ...
Nicolás Bartolomé Pérez
doaj +1 more source
Empleo de lenguas españolas no oficiales en Parlamentos autonómicos.
Revista de las Cortes Generales, 2021 El Tribunal Constitucional desestima el recurso de inconstitucionalidad interpuesto por más de cincuenta diputados del Grupo Parlamentario VOX en el Congreso contra el artículo 3 bis del Reglamento de la Junta General del Principado de Asturias ...
Alejandro Rastrollo Ripollés
doaj +1 more source