Results 111 to 120 of about 243,902 (282)
EQUILIBRIUM PRINCIPAL-AGENT CONTRACTS Competition and R&D Incentives [PDF]
We analyze competition between firms engaged in R&D activities in the choice of incentive contracts for managers with hidden productivities. The equilibrium screening contracts require extra effort/investment from the most productive managers compared to
Federico Etro, Michela Cella
core
Principal agent problems under loss aversion: an application to executive stock options [PDF]
, 2004 Executive stock options reward success but do not penalise failure. In contrast, the standard principalagent model implies that pay is normally monotonically increasing in performance.
de Meza, David, Webb, David C.
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A PRINCIPAL-AGENT MODEL FOR REGIONAL PEST CONTROL ADOPTION [PDF]
Investigating the underlying producer characteristics associated with regional pest control adoption revealed an interesting proposition. Early adopting producers of firm-specific techniques with characteristics including higher education, more ...
Ahouissoussi, Nicolas B.C.
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Contractual Mechanisms in National Park Management: A Multi-Task Principal–Agent Model
LandIn the management of national parks, the principal–agent relationship is key to efficient and effective management. Based on multi-task principal–agent theory, this study examines the dual functions of central government incentives and guidance and the ...
Mingxin Lin, Zuomin Wen
doaj +1 more source
Setting Incentives for Collaboration Among Agricultural Scientists: Application of Principal-Agent Theory to Team Work [PDF]
The USDA is attempting to shift more research funds into competitive grants involving collaboration across disciplines on large projects. This type of research structure raises a host of information and incentive issues.
Wallace E. Huffman
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Reducing the quality risk of elderly care services in government procurement from market-oriented private providers through ex ante policy design: lessons from the principal-agent theory analysis. [PDF]
BMC Health Serv Res, 2020 Song H, Yu S, Sun T.
europepmc +1 more source