Results 51 to 60 of about 250,500 (300)
Ensuring effective management of decentralized autonomous organizations under information asymmetry
Вестник университетаOne of the factors negatively affecting management effectiveness in decentralized autonomous organizations is implicit centralization of decision-making within a certain group of participants.
V. V. Abramov, G. V. Kolesnik
doaj +1 more source
Agent–Principal Dilemma and the EU Chemical Management
Baltic Journal of European studies, 2018 In 2007, the EU adopted the most comprehensive chemical regulation in the world. The so-called REACH requires all chemical producers and importers to register and evaluate their chemical products and, when necessary, replace them with safer alternatives.
Filipec Ondřej
doaj +1 more source
The role of the agent's outside options in principal-agent relationships [PDF]
, 2009 We consider a principal-agent model of adverse selection where, in order to trade with the principal, the agent must undertake a relationship-specific investment which affects his outside option to trade, i.e.
A. Darwiche +12 more
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Countervailing Conflicts of Interest in Delegation Games
Games, 2023 In this paper, we investigate optimal delegation mechanisms in the presence of countervailing conflicts of interest in the context of principal–agent problems.
Saori Chiba, Kaiwen Leong
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Regional determinants of residential energy expenditures and the principal-agent problem in Austria
REGION, 2015 The aim of this paper is two-fold: 1) to examine the determinants of residential energy expenditures and compare them on a regional level; and, 2) attempt to identify and measure the effect of possible principal-agent (PA) problems on residential energy ...
Daniel R. Hill
doaj
Conditional Analysis and a Principal-Agent problem
, 2016 We analyze conditional optimization problems arising in discrete time Principal-Agent problems of delegated portfolio optimization with linear contracts.
Backhoff, Julio, Horst, Ulrich
core +1 more source