Results 51 to 60 of about 799,212 (303)

Hybrid Multiagent Collaboration for Time-Critical Tasks: A Mathematical Model and Heuristic Approach

Algorithms, 2021
Principal–assistant agent teams are often employed to solve tasks in multiagent collaboration systems. Assistant agents attached to the principal agents are more flexible for task execution and can assist them to complete tasks with complex constraints ...
Yifeng Zhou, Kai Di, Haokun Xing
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Does Fiscal Decentralization in Indonesia have Asymmetrical Information?: Principal-Agent Model, Primal-Dual, and a Neural Network Analysis

Eko-Regional, 2019
In reality, subnational governments suffer from moral hazard, creating uncertainty which, in turn, causes economic inefficiency. The behavior of subnational governments cannot be observed by the central government.
Kun Haribowo
doaj   +1 more source

Reinvention and the Principal-Agent Model [PDF]

, 2002
Existe una interesante polémica en el sector público, derivada de las tensiones existentes entre desempeño y flexibilidad administrativa por un lado, y rendición de cuentas y control, por el otro. El propósito de este artículo es discutir la utilidad del
GIL GARCIA, JOSE RAMON, GIL GARCIA, JOSE RAMON   +1 more
core  

Moral Hazard in Dynamic Risk Management [PDF]

, 2015
We consider a contracting problem in which a principal hires an agent to manage a risky project. When the agent chooses volatility components of the output process and the principal observes the output continuously, the principal can compute the ...
Cvitanić, Jakša, Possamaï, Dylan, Touzi, Nizar   +2 more
core   +5 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

CORRUPTION AS AN INSTITUTE OF COMMUNICATION IN THE ‘PRINCIPAL – AGENT’ MODEL

Вестник Кемеровского государственного университета, 2015
In terms of the ‘principal-agent model’ corruption can be defined as violation of the contract (formal or informal) between the agent and the principal. The resources provided by the principal are then used by the agent for their private needs. From this
N. К. Dyatlova, Ya. A. Tsader
doaj  

LIMITED DELEGATION AND FIRM CONTROL: A PRINCIPAL-AGENT ACCOUNT OF SOUTHERN AFRICAN DEVELOPMENT COMMUNITY (SADC) DECISION-MAKING ON ZIMBABWE’S LAND ISSUE

Journal of International Studies, 2021
This paper accounts for Southern African Development Community (SADC) decision-making on Zimbabwe’s land issue from the year 2000 onwards. Guided by the principal-agent model, this paper argues that the delegation and control dynamics emerging from SADC’
Fungayi Promote Maraire, Mohd. Azizuddin bin Mohd Sani, Siti Darwinda Binti Mohamed Pero   +2 more
doaj  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source