Results 61 to 70 of about 658,976 (287)

The State and the Development of Industrial Plantation Forest

Jurnal Manajemen Hutan Tropika, 2014
Development of industrial plantation forest is a form of principal-agent relationship, in which the Ministry of Forestry as a principal gives utilization permit to the entrepreneur as an agent, known as the Forest Timber Product Exploitation Permit on ...
Sudarmalik, Hariadi Kartodihardjo, Sudarsono Soedomo, Soeryo Adiwibowo   +3 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Contractual Mechanisms in National Park Management: A Multi-Task Principal–Agent Model

Land
In the management of national parks, the principal–agent relationship is key to efficient and effective management. Based on multi-task principal–agent theory, this study examines the dual functions of central government incentives and guidance and the ...
Mingxin Lin, Zuomin Wen
doaj   +1 more source

Incentive Mechanism for Inhibiting Developer’s Moral Hazard Behavior in China’s Sponge City Projects

Advances in Civil Engineering, 2019
As a new sustainable urban development concept, the Sponge city has an important influence on the stormwater treatment. The low-impact development (LID) system of nonpublic lands plays an important role in the entire construction of Sponge city.
Han Han, Zhuofu Wang, Huimin Li
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Local health governance in Tajikistan: accountability and power relations at the district level

International Journal for Equity in Health, 2020
Background Relationships of power, responsibility and accountability between health systems actors are considered central to health governance. Despite increasing attention to the role of accountability in health governance a gap remains in understanding
Eelco Jacobs, Claudia Baez Camargo
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Mapping The Principal-Agent Relation In Social Media: A Data Mining Approach

JAKP (Jurnal Administrasi dan Kebijakan Publik), 2019
Most of the research on social media is conducted to comprehend and to exploit the presence of public opinion in it. Meanwhile, there has been limited research that explores the engagement process and interaction results from social media accounts ...
Ujang Fahmi, Canggih Puspo Puspo Wibowo, Faturahman Yudanto Yudanto   +2 more
doaj   +1 more source

Effects of Internationalization on Ownership Structure: Evidence from Latin American Firms [PDF]

BAR: Brazilian Administration Review, 2014
We analyze the direct and simultaneous effects of internationalization on the ownership structure of Latin American companies based on agency theory.
Hsia Hua Sheng, Vinícius Silva Pereira
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source