Results 61 to 70 of about 658,036 (304)

Incentive Mechanism for Inhibiting Developer’s Moral Hazard Behavior in China’s Sponge City Projects

Advances in Civil Engineering, 2019
As a new sustainable urban development concept, the Sponge city has an important influence on the stormwater treatment. The low-impact development (LID) system of nonpublic lands plays an important role in the entire construction of Sponge city.
Han Han, Zhuofu Wang, Huimin Li
doaj   +1 more source

Local health governance in Tajikistan: accountability and power relations at the district level

International Journal for Equity in Health, 2020
Background Relationships of power, responsibility and accountability between health systems actors are considered central to health governance. Despite increasing attention to the role of accountability in health governance a gap remains in understanding
Eelco Jacobs, Claudia Baez Camargo
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Effects of Internationalization on Ownership Structure: Evidence from Latin American Firms [PDF]

BAR: Brazilian Administration Review, 2014
We analyze the direct and simultaneous effects of internationalization on the ownership structure of Latin American companies based on agency theory.
Hsia Hua Sheng, Vinícius Silva Pereira
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Contractual Mechanisms in National Park Management: A Multi-Task Principal–Agent Model

Land
In the management of national parks, the principal–agent relationship is key to efficient and effective management. Based on multi-task principal–agent theory, this study examines the dual functions of central government incentives and guidance and the ...
Mingxin Lin, Zuomin Wen
doaj   +1 more source

Mapping The Principal-Agent Relation In Social Media: A Data Mining Approach

JAKP (Jurnal Administrasi dan Kebijakan Publik), 2019
Most of the research on social media is conducted to comprehend and to exploit the presence of public opinion in it. Meanwhile, there has been limited research that explores the engagement process and interaction results from social media accounts ...
Ujang Fahmi, Canggih Puspo Puspo Wibowo, Faturahman Yudanto Yudanto   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

European Policymaking: An Agency-Theoretic Analysis of the Issue [PDF]

In various European legal acts the Council has delegated power to the Commission to set common policy, conditional on specific procedural requirements, which are commonly known as "comitology".
Bernard Steunenberg, Dieter Schmidtchen
core   +4 more sources