Results 111 to 120 of about 809,351 (338)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

The Quality-Quantity Trade-off in the Principal-Agent Framework [PDF]

open access: yes
This paper uses the principal-agent theory to analytically investigate the optimal incentive-based compensation contract that a processor should offer to a grower performing efforts in quantity and quality.
Martinez, Jorge Rosell   +1 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

Horizontal and Vertical Social Preferences in Tournaments [PDF]

open access: yes
Most studies find no collusion in tournaments. This result suggests that social preferences are irrelevant in this context. We investigate the impact of social preferences in a tournament using data from a laboratory experiment with two treatments.
Gerald Eisenkopf, Sabrina Teyssier
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Externalities and the Allocation of Decision Rights in the Theory of the Firm [PDF]

open access: yes
This paper views authority as the right to undertake decisions that have external effects on other members of the organization. Because of contractual incompleteness, monetary incentives are insufficient to internalize these effects in the decision maker’
Bester, Helmut
core  

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim   +3 more
wiley   +1 more source

Integrated demand response optimization strategy considering risk appetite under multi‐dimensional uncertain information

open access: yesIET Generation, Transmission & Distribution
Integrated demand response (IDR) is deemed as an effective tool to balance energy supply and demand. User’s uncertain information containing prior uncertain information and posterior uncertain information is a key factor affecting the implementation ...
Shunlin Zheng   +7 more
doaj   +1 more source

Between Autonomy and Control: Influencer-Marketers Relations and Campaign Development

open access: yesRomanian Journal of Communications and Public Relations
Social media influencers have complex advertising functions as content creators and managers of their social media channels. The present research investigates the interaction processes between marketers and social media influencers during the ...
Anca Broască   +2 more
doaj   +1 more source

Optimal contracts in a dynamic costly state verification model [PDF]

open access: yes
This paper describes optimal contracts in a dynamic costly state verification model with stochastic monitoring. An agent operates a risky project on behalf of a principal over several periods.
Monnet, Cyril, Quintin, Erwan
core  

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