Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu+9 more
wiley +1 more source
Aridity-induced structural and functional adaptations in Solanum surattense across dryland ecosystems. [PDF]
Rafiq S+12 more
europepmc +1 more source
Boundedness of semistable principal bundles on a curve, with classical semisimple structure groups
Nitin Nitsure
openalex +2 more sources
CD9‐association with PIP2 areas is regulated by a CD9 salt bridge
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi+2 more
wiley +1 more source
Nitric oxide‐forming nitrite reductases in the anaerobic ammonium oxidizer Kuenenia stuttgartiensis
Anammox bacteria remove fixed nitrogen from their environment via anaerobic ammonium oxidation (anammox) with nitrite as electron acceptor and dinitrogen gas as product. The first anammox step is the conversion of nitrite to nitric oxide by nitrite reductase.
Femke J. Vermeir+4 more
wiley +1 more source
Optimising older People's Transition from acute care Into residential aged care through Multidisciplinary Assessment and Liaison (OPTIMAL): protocol for a stepped wedge cluster randomised controlled trial with embedded process evaluation. [PDF]
Fernando RL+13 more
europepmc +1 more source
Harder–Narasimhan reduction of a principal bundle [PDF]
Indranil Biswas, Yogish I. Holla
openalex +1 more source
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu+12 more
wiley +1 more source
Osmotic pressure‐induced calcium response states
Acute hypotonic stress triggers distinct calcium response patterns in HEK293T cells. These signals originate from the endoplasmic reticulum via RyR2 and propagate to neighboring cells through gap junctions. This result highlights a novel calcium‐dependent mechanism underlying the intracellular and intercellular response to osmotic pressure.
Zidan Gao+2 more
wiley +1 more source
Effectiveness of the GPT-4o Model in Interpreting Electrocardiogram Images for Cardiac Diagnostics: Diagnostic Accuracy Study. [PDF]
Engelstein H+6 more
europepmc +1 more source