Results 221 to 230 of about 2,005,987 (380)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI. [PDF]

Eur Radiol Exp
Ricchi M, Campani G, Nagmutdinova A, Bortolotti V, Greco D, Golini C, Grist J, Brizi L, Testa C.   +8 more
europepmc   +1 more source

Principal Bundles, Connections and BRST Cohomology

, 1994
Hugo Garcı́a-Compeán, J. M. López-Romero, M. A. Rodríguez-Segura, M. Socolovsky   +3 more
openalex   +2 more sources

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Relational quantum geometry

Nuclear Physics B
A common feature of the extended phase space of gauge theory, the crossed product of quantum theory, and quantum reference frames (QRFs) is the adjoining of degrees of freedom followed by a constraining procedure for the resulting total system.
Shadi Ali Ahmad, Wissam Chemissany, Marc S. Klinger, Robert G. Leigh   +3 more
doaj  

Symplectic Geometry of Teichmüller Spaces for Surfaces with Ideal Boundary. [PDF]

Commun Math Phys
Alekseev A, Meinrenken E.
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

On the principal bundles with parabolic structure [PDF]

, 2003
Indranil Biswas
openalex   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

Managing obstetric bleeding in Wales: A qualitative evaluation of the OBS Cymru care bundle using Normalisation Process Theory. [PDF]

PLoS One
Rai T, Hinton LE, Mackay R, Black M, Sanders J, Slade P, Elsmore A, Dhadda A, Parry-Smith W, Collis R, Petrou S, Stanworth S, Pallman P, Townson J, Fye H, Geden AG, Collins P, Bell S.   +17 more
europepmc   +1 more source