Results 211 to 220 of about 2,362,828 (289)

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Cross-site quantitative MRI harmonization: The impact on age modeling in health and disease. [PDF]

Imaging Neurosci (Camb)
Chen X, Ocampo-Pineda M, Lu PJ, Ekerdt C, Weigel M, Jansen MG, Cagol A, Chan KS, Schädelin S, Zwiers M, Oosterman JM, Norris DG, Bayer JMM, Marquand AF, Menks WM, Kuhle J, Kappos L, Melie-Garcia L, Granziera C, Marques JP.   +19 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The perineurium integrates leptin with its sympathetic outflow to protect against obesity. [PDF]

Nat Metab
Sarker G, Haberman E, Chandran A, Monfeuga T, Maroteau C, Lundh S, Oliveira DS, Raimondi A, Ziegler K, Gomes T, Cordeiro TN, Parekh K, Schmid E, Fernández-Sanmartín P, Griebel A, Martinez-Sanchez N, Arús BA, Cheung SW, Zhu Y, Shaked M, Knowles SCL, Engelhardt SH, Iannacone M, Scherer PE, López M, Toledo EM, Domingos AI.   +26 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

A Guide to Developing a Neurosurgery Quality Dashboard From Scratch: A Technical Report. [PDF]

Cureus
Ali A, Joseph C.
europepmc   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Quality differentiation and salidroside biosynthesis in <i>Rhodiola crenulata</i>, <i>R. fastigiata</i>, and intergrades. [PDF]

Front Plant Sci
Mo C, Wang Q, Si B, Yan M, Zeng C, Lu Y, Ren D, Chen W, Ni Z, Chen H, Xu B, Yu M, Wei J.   +12 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Trade-Offs and Synergies Among Ecosystem Services Influenced by Forest Type and Their Implications for Spatial Management in the Upper Minjiang River Basin, China. [PDF]

Plants (Basel)
Hong L, Zhang G, Cong N, Bai M, Ren P, Xiao J.   +5 more
europepmc   +1 more source