Results 201 to 210 of about 4,208,641 (395)

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

Molecular Oncology, EarlyView.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana, Paloma Navarro, Iván Hernández, Alejandra Ramos, Ana Montero‐Calle, Pablo Cabezas‐Sainz, Maria J Barrero, Diego Megías, Borja Vilaplana‐Martí, Carolina Epifano, Déborah Gómez‐Dominguez, Sara Monzón, Isabel Cuesta, Laura Sánchez, Rodrigo Barderas, Jesús García‐Donas, Alberto Martín, Ignacio Pérez de Castro   +17 more
wiley   +1 more source

ILLUSTRATIVE EXAMPLES OF PRINCIPAL COMPONENTS ANALYSIS

, 1987
Walter T. Fédérer, Charles E. McCulloch, N. J. Miles-McDermott   +2 more
openalex   +2 more sources

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Application of Principal Component Analysis as a Prediction Model for Feline Sporotrichosis. [PDF]

Vet Sci
Pegoraro FB, Mangrich-Rocha RMV, Weber SH, de Farias MR, Schmidt EMDS.   +4 more
europepmc   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

Rejoinder: Analysis of Additive Dependencies and Concurvities Using Smallest Additive Principal Components [PDF]

, 1994
Deborah Donnell, Andreas Buja, Werner Stuetzle   +2 more
openalex   +1 more source

Cerebrovascular accident and essential and toxic metals: cluster analysis and principal component analysis. [PDF]

BMC Pharmacol Toxicol
Nezami H, Kooshki A, Esmaily H, Sanjari M, Ahmadi Z, Sadeghi M, Mosavi Mirzaei SM.   +6 more
europepmc   +1 more source

Quantitative gait evaluation of hip diseases using principal component analysis

, 1983
Sumiko Yamamoto, Yasuo Suto, Hiroshi Kawamura, Tsutomu HASHIZUME, S Kakurai, Satoru SUGAHARA   +5 more
openalex   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Integration of Artificial Neural Network Regression and Principal Component Analysis for Indoor Visible Light Positioning. [PDF]

Sensors (Basel)
Fite NB, Wegari GM, Steendam H.
europepmc   +1 more source