Results 31 to 40 of about 14,552 (202)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Research on geometrical characteristics of straight bevel gears with a small shaft angle with a non-generated gear and generated pinion [PDF]
FME Transactions, 2017 Based on the precessional bevel gears with a small shaft angle, a number of drives for oil and gas equipment have been developed. They are characterized by high efficiency (about 0.9) and a small starting torque. Due to multi-pair tooth meshing they have
Syzrantsev Vladimir +3 more
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Lines of Principal Curvature near Singular End Points of Surfaces in R3
, 2005 In this paper are studied the nets of principal curvature lines on surfaces embedded in Euclidean $3-$space near their end points, at which the surfaces tend to infinity. This is a natural complement and extension to smooth surfaces of the work of Garcia and Sotomayor (1996), devoted to the study of principal curvature nets which are structurally ...
Sotomayor, Jorge, Garcia, Ronaldo
openaire +2 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Sweeping Surfaces of Polynomial Curves in Euclidean 3-space
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria MatematicaIn this study, we investigate the surfaces created by the movement of the profile curves through the regular polynomial spine curves. To overcome the restrictions of establishing a frame of the polynomial curves at the points where the second and higher ...
Zhu Yuting +3 more
doaj +1 more source
Information-Geometric Models in Data Analysis and Physics
MathematicsInformation geometry provides a data-informed geometric lens for understanding data or physical systems, treating data or physical states as points on statistical manifolds endowed with information metrics, such as the Fisher information.
D. Bernal-Casas, José M. Oller
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source