Results 51 to 60 of about 326,550 (311)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Transfer of the GPIT Property in Pullbacks

International Journal of Mathematics and Mathematical Sciences, 2012
Let 𝑇 be a commutative ring, 𝐼 a prime ideal of 𝑇, 𝐷 a subring of 𝑇/𝐼, and 𝑅 the pullback 𝑇×𝑇/𝐼𝐷. Ascent and descent results are given for the transfer of the 𝑛-PIT and GPIT (generalized principal ideal theorem) properties between 𝑇 and 𝑅.
David E. Dobbs, Jay Shapiro
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Principal ideal rings and a condition of Kummer

Journal of Algebra, 1983
Edwards [2] has delved into the history of the well-known story to the effect that Kummer thought he had a proof of Fermat’s last theorem, but Dirichlet pointed out to him that he was tacitly assuming that the ring Z[
Robert Gilmer, William Heinzer
openaire   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

On QF rings and artinian principal ideal rings

Hacettepe Journal of Mathematics and Statistics, 2017
In this work we give sufficient conditions for a ring $R$ to be quasi-Frobenius, such as $R$ being left artinian and the class of injective cogenerators of $R$-Mod being closed under projective covers. We prove that $R$ is a division ring if and only if $R$ is a domain and the class of left free $R$-modules is closed under injective hulls.
ALVARADO-GARCÍA, Alejandro, CEJUDO-CASTİLLA, César, RİNCÓN-MEJÍA, Hugo Alberto, VİLCHİS-MONTALVO, İvan Fernando, ZORRİLLA-NORİEGA, Manuel Gerardo   +4 more
openaire   +3 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

BENTUK NORMAL SMITH DAN MATRIKS BAIK KIRI / KANAN [PDF]

, 2009
The smith normal form and left good matrix have been known in matrix teorem. Any matriks over the principal ideal ring has a Smith normal form. The Smith normal form of a matrix has many applications on various fields such as a solution of Diaphantin ...
NOVITASARI, LAILY
core  

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source