Results 71 to 80 of about 397,514 (346)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

On generalized morphic modules

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica
Aim of the present article is to extend generalized morphic ring to modules. Let R be a commutative ring with a unity and M an R-module. M is said to be a generalized morphic module if for each m ∈ M, there exists a ∈ R such that annR (m) = (a) + annR (M
Çeken Seçil, Tekir Ünsal, Koç Suat
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Decomposition of finitely generated projective modules over Bezout ring [PDF]

open access: yesМатематичні Студії, 2013
It is shown that a commutative Bezout ring $R$ of stable range 2 isan elementary divisor ring if and only if for each ideal $I$ everyfinitely generated projective $R/I$-module is a direct sum ofprincipal ideals generated by idempotents.
B. V. Zabavsky, S. І. Bilavska
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

On Commutative Reduced Baer Rings [PDF]

open access: yesJournal of Sciences, Islamic Republic of Iran, 2004
It is shown that a commutative reduced ring R is a Baer ring if and only if it is a CS-ring; if and only if every dense subset of Spec (R) containing Max (R) is an extremally disconnected space; if and only if every non-zero ideal of R is essential in a ...
doaj  

On Property (A) and the socle of the $f$-ring $Frm(mathcal{P}(mathbb R), L)$ [PDF]

open access: yesCategories and General Algebraic Structures with Applications, 2018
For a frame $L$, consider the $f$-ring $ mathcal{F}_{mathcal P}L=Frm(mathcal{P}(mathbb R), L)$. In this paper, first we show that each minimal ideal of $ mathcal{F}_{mathcal P}L$ is a principal ideal generated by $f_a$, where $a$ is an atom of $L$.
Ali Asghar Estaji   +2 more
doaj  

Principal ideals in matrix rings

open access: yesJournal of Research of the National Bureau of Standards, Section B: Mathematical Sciences, 1969
Let R be a ring with a unity 1, and let n be a positive integer. It is well-known [3, p. 37]1 that every two-sided ideal of R" (the complete matrix ring of order n over R) is necessarily of the form M", where M is a two-sided ideal of R. Simple examples show that this result no longer holds for one-sided ideals.
Newman, Morris, Pierce, Stephen
openaire   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

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