Results 171 to 180 of about 469,727 (312)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Low-Temperature Co-Fermentation of <i>Lactobacillus bulgaricus 134</i> and <i>Saccharomyces cerevisiae</i>: Effects on Polyphenols Composition, Flavor Compounds and Antioxidant Activity of Black Rice Slurry. [PDF]

Foods
Xu Z, Nie C, Chen Z, Liu B.
europepmc   +1 more source

Dynamic Contracting with Persistent Shocks

In this paper, we develop continuous-time methods for solving dynamic principal-agent problems in which the agent's privately observed productivity shocks are persistent over time.
Zhang, Yuzhe
core  

<i>Poria cocos</i> Solid-State Fermentation for Bioprocessing Tartary Buckwheat: Nutritional Enhancement, Antioxidant Activity, and Application in Steamed Bread. [PDF]

Foods
Fan W, Tan B, Song B, Zhang B, Wang L, Wang Z, Jiang B.   +6 more
europepmc   +1 more source

Participation Rights and Mechanism Design [PDF]

This paper is concerned with the procedural aspects of collective choice and the impact of the parties' participation rights on the optimal mechanism. We find that the mechanism designer generally benefits from the selective engagement of the agents-the ...
Peter S. Faynzilberg
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Effects of different <i>Forsythia suspensa</i> leaf drying methods on volatile profile, taste-active compounds, and functional properties of millet-forsythia biscuits. [PDF]

Front Nutr
Zhu J, Qin Y, Cui M, Shang Y, Li Y.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Investigation of the propagation behavior of hydraulic fractures and its influencing mechanisms in fractured reservoirs based on a hydromechanical coupling numerical model. [PDF]

Sci Rep
Liu Y, Gong X, Ma X.
europepmc   +1 more source

A Comprehensive Instrumental Analysis Framework for Assessing the Dissolvability and Taste Properties of Plant Extract Instant Granules. [PDF]

Foods
Ma X, Lin Z, Wang Y, Jiang H, Xie J, Gu Q, Hu Y, Luo G, Xu B.   +8 more
europepmc   +1 more source