Results 121 to 130 of about 191,225 (267)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Principals as Literacy Leaders: Confident, Credible and Connected

, 2011
This book is the result of research conducted during the Principals as Literacy Leaders (PALL) Pilot Project. PALL was funded by the Australian Government under the Literacy and Numeracy Pilots in Low SES Communities program. Some 60 Government, Catholic,
Dempster, Neil, Gaffney, Mike, Lock, Graeme, Robson, Greg, McKennariey, Kevin, Konza, Deslea   +5 more
core  

Passionate and proactive: the role of the secondary principal in leading curriculum change. [PDF]

, 2008
It is widely recognised that the leadership of school principals is a crucial factor in school-based curriculum change. With the recent introduction of a new national curriculum in New Zealand, schools will need to develop strategies to incorporate this ...
Morrison, Michele, Cooper, Beverley
core  

Decentralization and Effective Educational Leadership: Expectation versus Reality

IRJE (Indonesian Research Journal in Education), 2018
Decentralization is a management reform that is widely believed to promise a range of benefits in transforming society and the effectiveness of local governance.
CECEP SOMANTRI
doaj  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Evaluation of a secondary principals' preparation program

, 1983
The purpose of the study was to investigate what crucial tasks are performed by secondary school principals. Crucial tasks were identified as those validated by the practicing principals as being necessary for an effective principal to perform the job ...
Smalley, Shirley Frances Archibald
core  

Appraising beginning teachers: Principals' conceptions of competence [PDF]

, 1998
The focus of this study is the phenomenon of beginning teacher competence. The teacher registration process in the Australian state of Queensland is used as a context for the study with the intention of identifying issues relevant to beginning teacher ...
Thompson, Robert
core  

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source