Results 61 to 70 of about 2,246,970 (302)
ITALY: THE PRINCIPLE OF SOLIDARITY AS A PRINCIPLE OF EQUALITY [PDF]
, 2021 <p><span>As an aspirational principle and all-encompassing concept, solidarity infuses – more or less extensively – several federal and federal-like systems as a concept that tends to promote equality, social-rights, well-being, and friendship among and between the various players of a compound polity, even when it is not clearly spelled in
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
ADMINISTRATIVE RESPONSIBILITY (THE CONSTITUTIONAL DESIGN)
Гуманитарные и юридические исследования, 2021 The article studies basic elements of the constitutional design of the administrative responsibility: proportionality of the restriction of citizens' rights and freedoms to the constitutionally signiicant interests and goals; presence of guilt as an ...
I. V. Maximov
doaj
Exploring an extention of Dick’s “intelligence principle” [PDF]
S&F_scienzaefilosofia.it, 2023 Exploring an extension to Dick's "intelligence principle" Revisiting Dick’s “Intelligence Principle” in the light of recent technological developments, I present an argument for why one might consider a slight extension to the Principle and I explore ...
Webb, Stephen
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
PRINCIPLES OF WASTE MANAGEMENT: PROBLEMS AND SOLUTIONS
Гуманитарные и юридические исследования, 2021 This article argues that in a complex environmental situation in the sphere of production and consumption waste management the legislator pays particular attention not only to the formulation of legal rules to solve this problem, but the special ...
Anatolij Ryzhenkov
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Is it the Principal Principle that Implies the Principle of Indifference? [PDF]
, 2017 Hawthorne et al. (Br J Philos Sci, http://bjps.oxfordjournals.org/lookup/doi/10.1093/bjps/axv030) argue that the Principal Principle implies a version of the Principle of Indifference. We show that what the Authors take to be the Principle of Indifference can be obtained without invoking anything which would seem to be related to the Principal ...
Gyenis, Balázs, Wroński, Leszek
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Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source