Results 111 to 120 of about 1,176,274 (256)
Complexity, Climate Change and the Precautionary Principle [PDF]
The precautionary principle has been proposed as a basis making decisions about environmental health under conditions of uncertainty, but remains controversial.
John Quiggin
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
A process of transformation of institucional’nykh terms is in the enterprise environment of Russia
Ученые записки Российской академии предпринимательства, 2021 In the article the process of transformation of changes is examined in development of enterprise environment in Russia. Basis ofenterprise environment is freedom of businessman and any unworked out actions from the side of supervisory organs can result ...
A. M. Chernopyatov
doaj
Can Bayesian agents always be rational? A principled analysis of consistency of an Abstract Principal Principle [PDF]
, 2013 The paper takes the Abstract Principal Principle to be a norm demanding that subjective degrees of belief of a Bayesian agent be equal to the objective probabilities once the agent has conditionalized his subjective degrees of beliefs on the values of ...
Rédei, Miklós, Gyenis, Zalán
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Applying the Precautionary Principle to Hidden Collapse [PDF]
There is growing evidence around the world of serious decline in biodiversity requiring urgent application of precautionary risk management. A better regulatory regime for precautionary management of long-term risk is now an urgent priority. This article
Martin, Rhett D. +4 more
core +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
On the formal statement of the special principle of relativity [PDF]
, 2011 The aim of the paper is to develop a proper mathematical formalism which can help to clarify the necessary conceptual plugins to the special principle of relativity and leads to a deeper understanding of the principle in its widest ...
Gomori, Marton, Szabo, Laszlo E.
core
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source