Results 81 to 90 of about 2,159,427 (297)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Islamic Foreign Policy Principles Derived from the Covenants of Prophet Muhammad [PDF]
Journal of Islamic Political StudiesCountries often establish principles to guide their foreign policies, often prioritizing their own interests over those of others. This paper will explore Islamic principles of foreign policy, drawing from the covenants of Prophet Muhammad. The Prophet’s
Abubakar Salati +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Diagnosis of English Language Teaching in Public Elementary Schools in Pasto, Colombia
HOW, 2011 English teaching in Colombian primary schools became a requirement because of the promulgation of the Law of Education in 1994. Taking into account that this decision produced some difficulties in the schools, a study was conducted to diagnose the state
Jesús Alirio Bastidas +1 more
doaj
Management principles of the interaction between market attractiveness producer and its recipients [PDF]
Marketing i Menedžment Innovacij, 2013 The aim of the article. The article is devoted to the definition of the content of interaction between attractiveness producer and its recipients through the prism of general and derived management principles.
O.V. Sviridova
doaj
Crusius et la certitude métaphysique en 1762
Astérion, 2011 This article aims to discuss the role played by Crusius’ thought in the genesis and the structure of Kant’s Preisschrift of 1762. Definitely opposed to Wolffian philosophy, Kant argues for the analythical method as the only method capable of ensuring a ...
Tinca Prunea-Bretonnet
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Critical reflections on the principle of beneficence in biomedicine
The Pan African Medical Journal, 2012 Medical ethics as a scholarly discipline and a system of moral principles that apply values and judgments to the practice of medicine encompasses its practical application in clinical settings as well as work on its history, philosophy, theology ...
Munyaradzi Mawere
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source