Results 131 to 140 of about 3,653,860 (344)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Apontamentos sobre a discussão acerca da supremacia do interesse público sobre o privado

Revista Interdisciplinar de Direito, 2014
Th is article examines the sense of the principle of the supremacy of the public interest over private, which is a public law canon, about the debate started by those who recently came to deny that standard, so as to know whether the attack deserves to ...
Fábio Corrêa de Souza Oliveira, Tamara Porto, Ursula Chaves, Larissa Tristão , Roberta Piluso, André Braz, Carlos Alberto Sousa   +5 more
doaj  

Principle of Uncertain Future [PDF]

The principle of uncertain future: the probability of a future event contains a degree of (hidden) uncertainty. As a result, this uncertainty (in a sense, similar to vibrations, fluctuations) pushes the probability value back from the bounds to the ...
Alexander Harin
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Can Bayesian agents always be rational? A principled analysis of consistency of an Abstract Principal Principle [PDF]

, 2013
The paper takes the Abstract Principal Principle to be a norm demanding that subjective degrees of belief of a Bayesian agent be equal to the objective probabilities once the agent has conditionalized his subjective degrees of beliefs on the values of ...
Rédei, Miklós, Gyenis, Zalán
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Principles? Principles? Who needs Principles? This is A PID Party!

, 2020
Presentation by Todd A. Carpenter, NISO Executive Directo and Committee Manager, ISO TC 46/SC 9, given at the Pidapalooza 2020 Conference in Lisbon Portugal. This talk consisted of background information about ISO identifiers work, and the development of the ISO Techincal Report - Principles of Identification (ISO DTR - 22943).
openaire   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The Right Not to Be Prosecuted, Judged, or Punished More Than One Time

ACROSS
In order to carry out the tasks of the criminal process, a regulation is necessary in accordance with certain ideas and guiding rules of its conduct. This function is fulfilled by the principles of the criminal process, by which the rules of a general ...
Dinu OSTAVCIUC
doaj   +1 more source