Results 91 to 100 of about 1,176,274 (256)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Imperfect Commitment and the Revelation Principle [PDF]
This paper extends the revelation principle to environments in which the mechanism designer cannot fully commit to the outcome induced by the mechanism.
Helmut Bester, Roland Strausz
core
The principle of legal certainty as a principle of economic efficiency
, 2014 Legal certainty, a feature of the rule of law, constitutes a requirement for the operational necessities of market interactions. But, the compatibility of the principle of legal certainty with ideals such as liberalism and free market economy must not ...
Gough, Orla +5 more
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
İBN SİNA MANTIĞINDA BURHANÎ BİLİMLERİN KONU, İLKE VE SORUNLARI
Felsefe Dünyası, 2012 Bu makalede İbn Sina’nın bilim felsefesinin önemli bir alanı olan bilimlerinkonu, ilke ve sorunları meselesi ele alınmaktadır. Bu bağlamda konununbilimler için önemi, konuları bakımından bilimler arasındaki fark ve ilişkiler, bilimlerinilkeleri olarak ...
Yusuf Daşdemir
doaj
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Cost Recovery for Water Services and the Polluter Pays Principle [PDF]
, 2009 This paper considers the general rationale for cost recovery pricing in respect of water services and examines the specific provision that is made for this, and related obligations, in Article 9 of the European Community Water Framework Directive ...
Howarth, William
core +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
, 2021 During language acquisition, children must learn when to generalize a pattern – applying it broadly and to new words (‘add –ed’ in English) – and when to restrict generalization, storing the pattern only with specific lexical items. But what governs when
Kathryn Schuler +2 more
core +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source