Results 111 to 120 of about 1,776,399 (318)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Imperfect Commitment and the Revelation Principle [PDF]
This paper extends the revelation principle to environments in which the mechanism designer cannot fully commit to the outcome induced by the mechanism.
Helmut Bester, Roland Strausz
core
On the formal statement of the special principle of relativity [PDF]
, 2011 The aim of the paper is to develop a proper mathematical formalism which can help to clarify the necessary conceptual plugins to the special principle of relativity and leads to a deeper understanding of the principle in its widest ...
Gomori, Marton, Szabo, Laszlo E.
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
A runoff system restores the principle of minimum differentiation [PDF]
, 1999 We show that the principle of minimum differentiation holds in two-round elections, for any number of candidates, regardless of the presence of entrants, or the distribution of voters preferences.
Volkerink, B.S.I. +7 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The principle of fairness : theory, defence, and application [PDF]
Theories of social justice propose various principles for the just regulation of social institutions and practices. However, why should individuals comply with the rules of just social institutions?
Kim, Dong-il
core
The Precautionary Principle in the EU & Its Impact on International Trade Relations. CEPS Working Document No. 186, October 2002 [PDF]
, 2002 [From the Abstract]. Although elements of precaution were used in the environmental regulation of various countries in the 1970s, including the United States, it has been the European Union that has emerged as the main proponent of the precautionary ...
Woolcock, Stephen.
core
Rabbanica: Journal of Revealed KnowledgeThis article discusses the application of the principle of original freedom (al-asl barÉah al-zimmah) according to Islamic jurisprudence and its implementation in current legislation in Malaysia.
Nik Faisal Nik Ismail
doaj