Results 71 to 80 of about 1,085,683 (268)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Principles of Interpretability
Notre Dame Journal of Formal Logic, 1999 A generalized Veltman semantics developed by de Jongh is used to investigate correspondences between several extensions of interpretability logic, IL. In this paper we present some new results on independences.
openaire +4 more sources
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
The reasonableness among the rule-making principles
Проблеми Законності, 2013 The article describes the principles on which the process of creation of the law is based. The role of reasonableness as rule-making requirement is explained.
К. О. Мандрікова
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Principles of the victim’s representation in criminal proceedings
Bulletin of Kharkiv National University of Internal AffairsBased on the analysis of the provisions of criminal procedure legislation, provisions of international legal treaties, and European Union law, and on the basis of generalisation of theoretical positions of scholars, and also taking into account the ...
I. O. Yemets
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Tyragetia, 2019 An important aspect of the professionalization of the museum sector is the institutionalization of the methods of competence assurance in the field. In this respect, an important indicator is the existence and implementation in practice of the Code of ...
Ploşniţa Elena
doaj
THE IMPORTANCE OF PRINCIPLES IN THE PRESENT CONTEXT OF LAW RECODIFYING [PDF]
Challenges of the Knowledge Society, 2012 In its grand historical-spatial diversity, in spite of the natural differences between civilizations, law presents a permanent and universal nature, represented by a bunch of constants.
ELENA ANGHEL
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source