Results 101 to 110 of about 2,246,970 (302)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Heparin Coating Technology in Cardiopulmonary Bypass

open access: yesMATEC Web of Conferences, 2017
Heparin coating technology has become increasingly mature, which is conducive to the material of blood, biocompatibility proved very important, therefore, heparin coating technique has become a development cycle is very useful for in vitro selection of ...
Zhang Kun, Xue Rui, Shen Shuwei
doaj   +1 more source

Cost Recovery for Water Services and the Polluter Pays Principle [PDF]

open access: yes, 2009
This paper considers the general rationale for cost recovery pricing in respect of water services and examines the specific provision that is made for this, and related obligations, in Article 9 of the European Community Water Framework Directive ...
Howarth, William
core   +1 more source

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Evaluating IMMPACT Criteria for the Clinical Meaningfulness of Between-Group Differences: Interpreting Randomized Trial Results within a Context of Existing Chronic Pain Analgesics

open access: yesJournal of Pain Research
Diana S Meske,1,2 Robert H Dworkin,3 Jeffrey Gudin,4 Nebojsa Nick Knezevic,5,6 Mark J Jaros,7 Kip Vought,2 Dmitri Lissin,8 Nathaniel Katz91Alivio Clinical Consulting, Chicago, IL, USA; 2Clinical Development, Medical Affairs, and Regulatory Affairs ...
Meske DS   +7 more
doaj  

Einstein, the reality of space, and the action-reaction principle [PDF]

open access: yes, 2013
Einstein regarded as one of the triumphs of his 1915 theory of gravity - the general theory of relativity - that it vindicated the action-reaction principle, while Newtonian mechanics as well as his 1905 special theory of relativity supposedly violated ...
Harvey R. Brown   +3 more
core  

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

open access: yesMolecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani   +7 more
wiley   +1 more source

BANKING ETHICS: MAIN CONCEPTIONS AND PROBLEMS [PDF]

open access: yesAnnals of the University of Petrosani: Economics, 2014
Banking ethics is a specialized set of ethical standards and rules that should be followed in the activities of financial institutions and employees of the banking sector.
VALENTINA FETINIUC, IVAN LUCHIAN
doaj  

MEANS OF PRESERVING NATIONAL VALUES IN EDUCATION, PATRIOTISM, AND UPBRINGING [PDF]

open access: yesVestnik Issyk-Kulʹskogo universiteta
This scientific and methodological work analyzes in detail the ways, of techniques and substantive features of patriotic education of elementary school students through artistic works.
Isakova S. T.   +2 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

open access: yesMolecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński   +12 more
wiley   +1 more source

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