Results 71 to 80 of about 1,086,404 (268)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The Principles of Interpretability

open access: yesNotre Dame Journal of Formal Logic, 1999
A generalized Veltman semantics developed by de Jongh is used to investigate correspondences between several extensions of interpretability logic, IL. In this paper we present some new results on independences.
openaire   +4 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The reasonableness among the rule-making principles

open access: yesПроблеми Законності, 2013
The article describes the principles on which the process of creation of the law is based. The role of reasonableness as rule-making requirement is explained.
К. О. Мандрікова
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Principles of the victim’s representation in criminal proceedings

open access: yesBulletin of Kharkiv National University of Internal Affairs
Based on the analysis of the provisions of criminal procedure legislation, provisions of international legal treaties, and European Union law, and on the basis of generalisation of theoretical positions of scholars, and also taking into account the ...
I. O. Yemets
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Principiile Codului deontologic al ICOM şi unele probleme de etică profesională din sistemul muzeal al Republicii Moldova / Principles of the ICOM Code of Ethics and some issues of professional ethics in the museum system of the Republic of Moldova

open access: yesTyragetia, 2019
An important aspect of the professionalization of the museum sector is the institutionalization of the methods of competence assurance in the field. In this respect, an important indicator is the existence and implementation in practice of the Code of ...
Ploşniţa Elena
doaj  

THE IMPORTANCE OF PRINCIPLES IN THE PRESENT CONTEXT OF LAW RECODIFYING [PDF]

open access: yesChallenges of the Knowledge Society, 2012
In its grand historical-spatial diversity, in spite of the natural differences between civilizations, law presents a permanent and universal nature, represented by a bunch of constants.
ELENA ANGHEL
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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